Results | viHumans

UniProt ID

Q00071

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]; Macaca (macaques) [TaxID: 9539]

Gene Name

Gag[Gene ID: 6386689 ]

Protein Name

♦Gag polyprotein (Pr71Gag) [Cleaved into: Gag protein (p68Gag)
♦ p3 (p3Gag)]

Organism Name

Simian Foamy Virus Type 1 (SFVmac) (SFV-1)

Taxonomic Lineage

Viruses> Retro-transcribing Viruses> Retroviridae> Spumaretrovirinae> Spumavirus> Simian Foamy Virus Type 1 (SFVmac) (SFV-1)

RefSeq

Not Available

PubMed ID

1647358 ; 1653483 ; 12908768 ; 15358259

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:6386689

Reactome

Not Available

Sequence

							MAAIEGDLDVQALANLFNDLGINRNPRHREVIALRMTGGWWGPATRYNLVSLLLQDDQGQPLPQPRWRAEGRAANPAVMFTLEAPWQDLRLAFDNIDVGE
GTLRFGPLANGNYIPGDEFSLEFLPPAMQEITQMQRDELEEVLDVVGQITMQMNDLIGMQDAQIRGLEGQLRGLRGNLPVAGTPPPPPPSLDLQPAAASS
PYVAPAPSAPAASAAAADLGWFAGGPGPGSLDPRLARVAYNPFLPGPSDGSGAAPAQPSAPPVASPLPSLLPAQPMQPVIQYVHPPPINPAQQVIPIQHI
RAVTGNAPSNPREIPMWIGRNASAIEGVFPIPTSDIRSRVINALLGRQLGLNLDPQHCITWASAIATLYVRTHGSYPLHQLAEVLRRVSNSEGAAAAWQL
GMMLTNQDYNLVWGMVRPLLPGQAVVTAMQHRLDQEVSDAARIVSFVNHLNAVYELLGLNARGQNLRVSTGGQTTARTSAGRGARGRRSQQGTPGRQSSG
QAPPQGRRSSQGQQPRQSESGDQNNQRQLQGGNNRGGYNLRPRTYQPQRYGGGRGRRWNDQTARADNQQRSQSQQPQSEARGEQSRTSGAGREQGGRGNQ
NRNQRSAGENTDRSVNTVTATSASISASGQNGSSTTPPASGSGNQGN
						

Length

647

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1993

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0003723 ; GO:0019013 ; GO:0019076 ; GO:0030430 ;
GO:0039702 ; GO:0042025 ; GO:0044163 ; GO:0046718 ; GO:0075521

Subcellular Location

♦ Gag protein: Virion . Host nucleus . Host cytoplasm . Note=Gag protein is nuclear at initial phase, cytoplasmic at assembly. Shortly after infection, Gag protein is targeted to centrosomes. It is then actively transported into the nucleus thanks to its nuclear localization signal. In the late phases of infection, Gag proteins assemble in the cytoplasm to form the virion's capsids (By similarity). .
♦ p3: Virion .

Domain(s)

Not Available

Motif(s)

MOTIF 258 261 PTAP/PSAP motif.; MOTIF 536 557 Nuclear localization signal.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available