Results | viHumans

UniProt ID

P90463

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

70[Gene ID: 4961481 ]

Protein Name

Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

Organism Name

Human Herpesvirus 8 Type P (isolate GK18) (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Rhadinovirus> Human Herpesvirus 8 (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)> Human Herpesvirus 8 Type P (isolate GK18) (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)

RefSeq

NC_009333.1 ; AF148805.2

PubMed ID

8962146 ; 9151804 ; 16760382

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:4961481

Reactome

Not Available

Sequence

							MFPFVPLSLYVAKKLFRARGFRFCQKPGVLALAPEVDPCSIQHEVTGAETPHEELQYLRQLREILCRGSDRLDRTGIGTLSLFGMQARYSLRDHFPLLTT
KRVFWRGVVQELLWFLKGSTDSRELSRTGVKIWDKNGSREFLAGRGLAHRREGDLGPVYGFQWRHFGAAYVDADADYTGQGFDQLSYIVDLIKNNPHDRR
IIMCAWNPADLSLMALPPCHLLCQFYVADGELSCQLYQRSGDMGLGVPFNIASYSLLTYMLAHVTGLRPGEFIHTLGDAHIYKTHIEPLRLQLTRTPRPF
PRLEILRSVSSMEEFTPDDFRLVDYCPHPTIRMEMAV
						

Length

337

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-05-1997

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Not Available

EC

2.1.1.45

Experimentally known GO terms

GO:0004799 ; GO:0006231 ; GO:0006235

Subcellular Location

Not Available

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

X-ray crystallography (3)

Experimetally known structure

5H38 5H39 5H3A

Active Site(s)

ACT_SITE 219 219 Nucleophile.

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available