Results | viHumans

UniProt ID

P89873

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

Bet

Protein Name

Protein Bet

Organism Name

Human Spumaretrovirus (SFVcpz(hu)) (Human Foamy Virus)

Taxonomic Lineage

Viruses> Retro-transcribing Viruses> Retroviridae> Spumaretrovirinae> Spumavirus> Simian Foamy Virus> Human Spumaretrovirus (SFVcpz(hu)) (Human Foamy Virus)

RefSeq

Not Available

PubMed ID

2820721 ; 19074429 ; 1846194 ; 11884565 ; 15994766 ; 15358259

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MDSYEKEESVASTSGIQDLQTLSELVGPENAGEGELTIAEEPEENPRRPRRYTKREVKCVSYHAYKEIEDKHPQHIKLQDWIPTPEEMIAQKVQNQDLGT
ILSFDVTCLKSITSLGRNDPGDDPSIMSHVLPVVTPWPMSQDHYAPTLFGILDRYYQGYLKSPATYQTWKFTCQVDPSGKRFMETQFWVPPLGQVNIQFY
KNYQILTCCQAVDPFANIFHGTDEEMFDIDSGPDVWCSPSLCFKVIYEGAMGQKQEQKTWLCRLGHGHRMGACDYRKVDLYAMRQGKENPYGDRGDAALQ
YAYQVKRGCKAGCLASPVLNYKALQFHRTIMADFTNPRIGEGHLAHGYQAAMEAYGPQRGSNEERVWWNVTRNQGKQGGEYYREGGEEPHYPNTPAPHRR
TWDERHKVLKLSSFATPSDIQRWTTKALPYGWKVVTESGNDYTSRRKIRTLTEMTQDEIRKRWESGYCDPFIDSGSDSDGPF
						

Length

482

Alternate Sequence

VAR_SEQ 1 126 Missing (in isoform Bel-2)

Non-standard residue

Not Available

Date of last Sequence modification

01-05-1997

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Bet counteracts the innate antiretroviral activity of APOBEC3 family defense factors by inhibiting their incorporation into virions. May be implicated in the establishment and/or maintenance of viral persistance. Bet is required for viral replication (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0005576 ; GO:0016032 ; GO:0030430 ; GO:0042025 ; GO:0045893

Subcellular Location

♦ Isoform Bet: Host cytoplasm . Host nucleus . Secreted . Note=Bet is highly expressed in infected cells, where it localizes to both cytoplasm and nucleus (). Also secreted and internalized by non-infected surrounding cells ().
♦ Isoform Bel-2: Host nucleus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available