Results | viHumans

UniProt ID

P89479

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

US11[Gene ID: 1487352 ]

Protein Name

Probable RNA-binding protein

Organism Name

Human Herpesvirus 2 (strain HG52) (HHV-2) (Human Herpes Simplex Virus 2)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Simplexvirus> Human Herpesvirus 2 (HHV-2) (Human Herpes Simplex Virus 2)> Human Herpesvirus 2 (strain HG52) (HHV-2) (Human Herpes Simplex Virus 2)

RefSeq

Not Available

PubMed ID

9499055

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1487352

Reactome

R-HSA-168255; R-HSA-168271; R-HSA-168275; R-HSA-168288; R-HSA-168298; R-HSA-168302; R-HSA-168303; R-HSA-168325; R-HSA-168330; R-HSA-168333; R-HSA-168336; R-HSA-192814; R-HSA-192823; R-HSA-192869; R-HSA-192905;

Sequence

							MASGVSPAHPQTPVGAGSRDLSLKGTPSDGMQPRGADTLEGHSLPTDGPPHRGGDHDPAAGKRGDSGLLRVCAALSIPKPSEAVRPSRIPRAPRVPREPR
VPREPREPRVPRSPREPRVPRIPRDPRPPRPPRVPREPRPPREPRATRGLA
						

Length

151

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-05-1997

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a role in the inhibition of host immune response. Participates in the inhibition of host autophagy by interacting with and inhibiting host PKR/EIF2AK2. This interaction also prevents the interferon-induced shut down of protein synthesis following viral infection. Downmodulates the host RLR signaling pathway via direct interaction with host DDX58 and IFIH1. May also participate in nuclear egress of viral particles through interactions with host NCL and regulation of the viral UL34 mRNA.

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0003723 ; GO:0030430 ; GO:0039502 ; GO:0039521 ;
GO:0039540 ; GO:0039554 ; GO:0039580 ; GO:0044196

Subcellular Location

Host nucleus, host nucleolus . Host cytoplasm . Note=Following infection, it is released into the cell cytoplasm. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available