Results | viHumans

UniProt ID

P89079

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

E4

Protein Name

E4-ORF1 (EC 3.6.1.23) (Early E4 14.0 kDa protein) (ORF1) (Probable dUTPase E4 ORF1)

Organism Name

Human Adenovirus D Serotype 9 (HAdV-9) (Human Adenovirus 9)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus D> Human Adenovirus D Serotype 9 (HAdV-9) (Human Adenovirus 9)

RefSeq

NC_010956.1 ; AJ854486.1

PubMed ID

8738606 ; 8189528 ; 9151828 ; 11000240

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MAESLYAFIDSPGGIAPVQEGTSNRYTFFCPESFHIPPHGVVLLHLKVSVLVPTGYQGRFMALNDYHARDILTQSDVIFAGRRQELTVLLFNHTDRFLYV
RKGHPVGTLLLERVIFPSVKIATLV
						

Length

125

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-05-1997

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein.

EC

3.6.1.23

Experimentally known GO terms

GO:0004170 ; GO:0009117 ; GO:0016032 ; GO:0030430

Subcellular Location

Host cytoplasm .

Domain(s)

Not Available

Motif(s)

MOTIF 122 125 PDZ-binding.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available