Results | viHumans

UniProt ID

P69520

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

RIR2[Gene ID: 1487327 ]

Protein Name

Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

Organism Name

Human Herpesvirus 2 (strain 333) (HHV-2) (Human Herpes Simplex Virus 2)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Simplexvirus> Human Herpesvirus 2 (HHV-2) (Human Herpes Simplex Virus 2)> Human Herpesvirus 2 (strain 333) (HHV-2) (Human Herpes Simplex Virus 2)

RefSeq

Not Available

PubMed ID

6321759 ; 6315408 ; 18990579

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1487327

Reactome

Not Available

Sequence

							MDPAVSPASTDPLDTHASGAGAAPIPVCPTPERYFYTSQCPDINHLRSLSILNRWLETELVFVGDEEDVSKLSEGELGFYRFLFAFLSAADDLVTENLGG
LSGLFEQKDILHYYVEQECIEVVHSRVYNIIQLVLFHNNDQARRAYVARTINHPAIRVKVDWLEARVRECDSIPEKFILMILIEGVFFAASFAAIAYLRT
NNLLRVTCQSNDLISRDEAVHTTASCYIYNNYLGGHAKPEAARVYRLFREAVDIEIGFIRSQAPTDSSILSPGALAAIENYVRFSADRLLGLIHMQPLYS
APAPDASFPLSLMSTDKHTNFFECRSTSYAGAVVNDL
						

Length

337

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

21-07-1986

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

EC

1.17.4.1

Experimentally known GO terms

GO:0004748 ; GO:0006260 ; GO:0009263 ; GO:0016021 ; GO:0019046 ;
GO:0033644 ; GO:0046872

Subcellular Location

♦ Host membrane
♦ Single-pass membrane protein .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

ACT_SITE 128 128

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available