Results | viHumans

UniProt ID

P68951

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

L2

Protein Name

Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like nucleoprotein (NP) (Core protein VII)]

Organism Name

Human Adenovirus C Serotype 5 (HAdV-5) (Human Adenovirus 5)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus C> Human Adenovirus C Serotype 5 (HAdV-5) (Human Adenovirus 5)

RefSeq

AC_000008.1 ;

PubMed ID

1727603 ; 3224820 ; 23142869 ; 7175505 ; 22754652 ; 22116065

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSILISPSNNTGWGLRFPSKMFGGAKKRSDQHPVRVRGHYRAPWGAHKRGRTGRTTVDDAIDAVVEEARNYTPTPPPVSTVDAAIQTVVRGARRYAKMKR
RRRRVARRHRRRPGTAAQRAAAALLNRARRTGRRAAMRAARRLAAGIVTVPPRSRRRAAAAAAAAISAMTQGRRGNVYWVRDSVSGLRVPVRTRPPRN
						

Length

198

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-02-2005

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0019028 ; GO:0044196 ; GO:0046718 ; GO:0075732

Subcellular Location

♦ Histone-like nucleoprotein: Virion . Note=Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion. .
♦ Pre-histone-like nucleoprotein: Host nucleus, host nucleolus .

Domain(s)

Not Available

Motif(s)

MOTIF 188 198 Nuclear localization signal.

Methods of 3D structure generation

Electron microscopy (1)

Experimetally known structure

6B1T

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available