Results | viHumans

UniProt ID

P59595

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]; Paguma Larvata (Masked Palm Civet) [TaxID: 9675]

Gene Name

N 9a[Gene ID: 1489678 ]

Protein Name

Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

Organism Name

Human SARS Coronavirus (SARS-CoV) (Severe Acute Respiratory Syndrome Coronavirus)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Nidovirales> Coronaviridae> Coronavirinae> Betacoronavirus> Severe Acute Respiratory Syndrome-related Coronavirus> Human SARS Coronavirus (SARS-CoV) (Severe Acute Respiratory Syndrome Coronavirus)

RefSeq

NC_004718.3 ; AY274119.3

PubMed ID

12730500 ;  12730501 ;  12853594 ;  12958366 ;  12876307 ;  12781537 ;  12917450 ;  14527350 ;  15351485 ;
15862300 ;  17210170 ;  19106108 ;  24766657 ;  15147189 ;  16041067 ;  16627473 ;  17379242 ;  17229691 ;
18561946 ;  20844028

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1489678

Reactome

Not Available

Sequence

							MSDNGPQSNQRSAPRITFGGPTDSTDNNQNGGRNGARPKQRRPQGLPNNTASWFTALTQHGKEELRFPRGQGVPINTNSGPDDQIGYYRRATRRVRGGDG
KMKELSPRWYFYYLGTGPEASLPYGANKEGIVWVATEGALNTPKDHIGTRNPNNNAATVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRGNSRNSTP
GSSRGNSPARMASGGGETALALLLLDRLNQLESKVSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKQYNVTQAFGRRGPEQTQGNFGDQDLIRQGTDYK
HWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYHGAIKLDDKDPQFKDNVILLNKHIDAYKTFPPTEPKKDKKKKTDEAQPLPQRQKKQPTVTLLPAAD
MDDFSRQLQNSMSGASADSTQA
						

Length

422

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

23-04-2003

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0019013 ; GO:0044172 ; GO:0044177 ; GO:0044220

Subcellular Location

Virion , , . Host endoplasmic reticulum-Golgi intermediate compartment , . Host Golgi apparatus , . Host cytoplasm, host perinuclear region . Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

X-ray crystallography (6); NMR spectroscopy (2)

Experimetally known structure

1SSK 1X7Q 2CJR 2GIB 2JW8 2OFZ 2OG3 3I6L

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available