Results | viHumans

UniProt ID

P52535

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

U49 LF2

Protein Name

Protein UL24 homolog

Organism Name

Human Herpesvirus 6A (strain GS) (HHV-6 Variant A) (Human B Lymphotropic Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Roseolovirus> Human Betaherpesvirus 6A> Human Herpesvirus 6A (strain GS) (HHV-6 Variant A) (Human B Lymphotropic Virus)

RefSeq

Not Available

PubMed ID

1654455

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSLTGLPDIRKKIGQFHHLRIYKQILSFQGNFARLNYFLGDVFPANLRSASVSVFFEVRLGPRIPDCIVLLKSVDVKDEFAFHCYFFEFKTTLGKSTMQS
VHHNCIHQAQYLQGLRQLQQSISFLDQYLIADEVSWNVVPVICFFRQWGLKLDFFKKFSGKTKRLSFSFIRDLFARSQDGAVQSLLSIPNYTNFRRACQK
HTDLYRKRCRKAPKSVLTKTSGENRSRASRQVAKNAPKNRIRRTAKKDAKRQ
						

Length

252

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1996

Protein Existence

Evidence at transcript level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0019012 ; GO:0044177 ; GO:0044196

Subcellular Location

Virion . Host cytoplasm . Host nucleus, host nucleolus . Host Golgi apparatus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available