Results | viHumans

UniProt ID

P52448

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

U70 CH3R[Gene ID: 1497070 ]

Protein Name

Alkaline nuclease (EC 3.1.-.-)

Organism Name

Human Herpesvirus 6B (strain Z29) (HHV-6 Variant B) (Human B Lymphotropic Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Roseolovirus> Human Herpesvirus 6B (HHV-6 Variant B) (Human B Lymphotropic Virus)> Human Herpesvirus 6B (strain Z29) (HHV-6 Variant B) (Human B Lymphotropic Virus)

RefSeq

NC_000898.1 ; AF157706.1

PubMed ID

8634027 ; 10482553

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1497070

Reactome

Not Available

Sequence

							MDLNQISETLSAVAEEEPLTMFLLDKLYAIREKIKQVPFSIVRLCHVYCMLIKYNASNNNCILGRKLIEEMQQFLCGARVDGSEDVSMDMSELCKLYDYC
PLLCSALCRAPCVFVNKLFKIVERETRGQSENPLWHALRRYTVTATKLYDIYTTRNFLEHKGQQFFGEAVIYGAKHERVIRHLVAIFYVKREVKETLGLL
LDPSSGVFGASLDACFGISFNEDGFLMVKEKALIFEIKFRYKYLRDKEDHFVSELLKNPTEKSFSDFILSHPVPAIEFRERGKIPSSREYLMTYDFQYRP
QRKLRTCPTPAILTPHIKQLLCLNETQTSTVIVFDCKSHLSEQKLSVFQKAVFTVNVFVNPKHRYFFQSLLQQYVMTQFYINDHSNPEYIESTEVPSVHI
VTALFRRRTEEERSLHLVIDETEYIEEEIPLALIVTPVAPNPEFTCRVITDICNLWENNICKQTSLQVWAQSAVNQYLAACVRKPKTP
						

Length

488

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1996

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.

EC

3.1.-.-

Experimentally known GO terms

GO:0003677 ; GO:0004519 ; GO:0004527 ; GO:0016032 ; GO:0030430 ;
GO:0042025

Subcellular Location

Host nucleus . Host cytoplasm .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available