Reviewed
Homo Sapiens (Human) [TaxID: 9606]
U31
Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
Human Herpesvirus 7 (strain JI) (HHV-7) (Human T Lymphotropic Virus)
Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Roseolovirus> Human Betaherpesvirus 7> Human Herpesvirus 7 (strain JI) (HHV-7) (Human T Lymphotropic Virus)
Various pathway(s) in which protein is involved
Not Available
Not Available
MRIIAGSTNQNDPKYGPRAGKQCMSNCFSFLHTVYLNGINNVLNKESIDIIMENGALLDNISTTTLKLETGNIPEYRFFTEIPKKISSNFGETIHELSRP
FNGTLESQHIDNEVYLGLLDFLLYGKNKKPAFIVITIGVMARAIFIVDELFYLFDSHASDTENSAAIYICEDIDELYALLAIENVAEFYYDAVFSYFIET
TDLSLEDGDATILILKTYKDPDIALSLNDFLTMYSSTSSTKTAETNTLISKQSPSKRKQEKTSLNSNSLEKKRKQGSSLKYYNNEVDLVPSFYELRPQFN
NILFELSNFPIVKENVNWTLYIQKFATKSTQPFTKPFIWNRVFHLFSQVVDALIMIKNDHWDETQQQKQFFTHFLPFKEFSEEFENAIEACRENNLDLIL
LYKNYLSKTTAFKNLERILLTKFSAIVSPVHEKHYTLVNTWLTNLIQKLVKHPEDTNAFINDYVLKNPLNHFICLNKKEKQSIALLLNKKRMSMLKDVEI
EKNGFVQLQAFIENIGEAPANYLDPENARKVNVEEVSEKDIPTLSTDKVSIPNESMFTSNKKHSIEKLIHAKLKAILSTMGQRLTRIIQENYNNIAAGFL
PVNDLNNLFAYLVKLYFDVYSITINGFVVENELIKNIEQIYDNTQYLRFGLTRFNMQNLTPFTISVRKMFLDFFLSQKTLIDRAEEIIENLEFKSVTPEG
KQKLATKNMLREQLEQLNAMDVDDTINLKTDTLTHQVLFSDQELRMIQDFILQLSIHNIPSINFVKSLKLHIILEKRPDILLALQEKVQNILYFYFQDLV
NEIPAQENVLSTMLFIIELFPADSRIHLLETGYISRHIVKKWLNMKSLQDAEDLIRFININKEQLGKFEHQPFGKEIQKLIEKIHLFYKQKVIEYQEDVW
SEMAKNIILTSPSELSQFLASAPTQRIIQKHKNNLDQKLLIHMENQAKQAMEDDKKRVACSKINLERHLNDLLLLLKDRQFASIQASVLIVCENIFKTIP
DDNLIIQFSHALLSVLLDIEKDLKSYSSEILEKILINRPLETSRLLVFKDAYGNLKEFLNALKQSLFATADVQNKADFLIQILDFTYKFRHKTNKGKLLH
SIYNEDFKLYEETLTELRKKATDAKESLTKLFKASEQKIELSRTIPLKEIYLNIETVNFQGYGNVVFRESAFKRAIEVEIKNYEMKLNDLIKHFNSHLKT
KIDHIQILNLSFDNKWKDFVSKSKISFPPELTISSQELIKDPIKVITETLNKASNDLAYVISEKILKWLIVFVKELNTFFVATMSEFGEVIPFDYKHFRA
LEYEINSKYIEIENKIICNEIIENTDNIEKLSTLIKQIDPNRIAGGKQKFQDYLSKILTAETNQQQTRYKEQLKKQYFDLLDNIAHFRFAFDFNHQQNLI
LKLKDKFKTLRTDTVFERFPNLDDTFVSSMNVENFLQALEALSHFVQAAQNFLQNVLTEQADLFPQTNFIPVELSTVKTIPKSDINLRMKIHTPQTFFQV
DSVFNTQLIVDEKGIPVQFYNVFHNIVFKFFALNYKKIIVPDKVLNLVSTKYKILTTLKSILSVVKSFWKEIINFDLTSYFQGKAEFTFQNVFPIINLKI
FIYIITQAWSVTSDETQHSFELPLEKFSLLIIANNPEFLFGSLQCPVDLAINSLIPLLEKKKYFTAFTISDNPPKLSMDELKIVCLDLNTWSEITLEKYT
FKKNSLMQLCMGKEKFFIYLLSALVLPQNFLNYIWIQYKPSCCAQDSFQQLIQDLCFEYTHQNHIKPISLNLQEPNALKHGERILSKFVLEKNANTSLFS
IFLGKQFLLDYLLFSYLTATEMTFSYYVDSIKNFLLTIRHLENVQQNVDFRTILQSRNFDLKYLLTQSWTQNVLEQSIFHVQLDKIIADIKQPQLSLKKI
PLVLFNGDNEVVSTYVPPEQASQTEQSFRIKNIFPNPVQEYSSKNVILFTNYPKNTKFLFNSPPPKTAAKSYKLPDTTDDINTETLSSPTIQRIPIKGLV
PKENEIVFLPEKNTAHTDSKETKTHLIDTFNILSQTKGEIKTFSTDFDQTISKLKHLYF
FNGTLESQHIDNEVYLGLLDFLLYGKNKKPAFIVITIGVMARAIFIVDELFYLFDSHASDTENSAAIYICEDIDELYALLAIENVAEFYYDAVFSYFIET
TDLSLEDGDATILILKTYKDPDIALSLNDFLTMYSSTSSTKTAETNTLISKQSPSKRKQEKTSLNSNSLEKKRKQGSSLKYYNNEVDLVPSFYELRPQFN
NILFELSNFPIVKENVNWTLYIQKFATKSTQPFTKPFIWNRVFHLFSQVVDALIMIKNDHWDETQQQKQFFTHFLPFKEFSEEFENAIEACRENNLDLIL
LYKNYLSKTTAFKNLERILLTKFSAIVSPVHEKHYTLVNTWLTNLIQKLVKHPEDTNAFINDYVLKNPLNHFICLNKKEKQSIALLLNKKRMSMLKDVEI
EKNGFVQLQAFIENIGEAPANYLDPENARKVNVEEVSEKDIPTLSTDKVSIPNESMFTSNKKHSIEKLIHAKLKAILSTMGQRLTRIIQENYNNIAAGFL
PVNDLNNLFAYLVKLYFDVYSITINGFVVENELIKNIEQIYDNTQYLRFGLTRFNMQNLTPFTISVRKMFLDFFLSQKTLIDRAEEIIENLEFKSVTPEG
KQKLATKNMLREQLEQLNAMDVDDTINLKTDTLTHQVLFSDQELRMIQDFILQLSIHNIPSINFVKSLKLHIILEKRPDILLALQEKVQNILYFYFQDLV
NEIPAQENVLSTMLFIIELFPADSRIHLLETGYISRHIVKKWLNMKSLQDAEDLIRFININKEQLGKFEHQPFGKEIQKLIEKIHLFYKQKVIEYQEDVW
SEMAKNIILTSPSELSQFLASAPTQRIIQKHKNNLDQKLLIHMENQAKQAMEDDKKRVACSKINLERHLNDLLLLLKDRQFASIQASVLIVCENIFKTIP
DDNLIIQFSHALLSVLLDIEKDLKSYSSEILEKILINRPLETSRLLVFKDAYGNLKEFLNALKQSLFATADVQNKADFLIQILDFTYKFRHKTNKGKLLH
SIYNEDFKLYEETLTELRKKATDAKESLTKLFKASEQKIELSRTIPLKEIYLNIETVNFQGYGNVVFRESAFKRAIEVEIKNYEMKLNDLIKHFNSHLKT
KIDHIQILNLSFDNKWKDFVSKSKISFPPELTISSQELIKDPIKVITETLNKASNDLAYVISEKILKWLIVFVKELNTFFVATMSEFGEVIPFDYKHFRA
LEYEINSKYIEIENKIICNEIIENTDNIEKLSTLIKQIDPNRIAGGKQKFQDYLSKILTAETNQQQTRYKEQLKKQYFDLLDNIAHFRFAFDFNHQQNLI
LKLKDKFKTLRTDTVFERFPNLDDTFVSSMNVENFLQALEALSHFVQAAQNFLQNVLTEQADLFPQTNFIPVELSTVKTIPKSDINLRMKIHTPQTFFQV
DSVFNTQLIVDEKGIPVQFYNVFHNIVFKFFALNYKKIIVPDKVLNLVSTKYKILTTLKSILSVVKSFWKEIINFDLTSYFQGKAEFTFQNVFPIINLKI
FIYIITQAWSVTSDETQHSFELPLEKFSLLIIANNPEFLFGSLQCPVDLAINSLIPLLEKKKYFTAFTISDNPPKLSMDELKIVCLDLNTWSEITLEKYT
FKKNSLMQLCMGKEKFFIYLLSALVLPQNFLNYIWIQYKPSCCAQDSFQQLIQDLCFEYTHQNHIKPISLNLQEPNALKHGERILSKFVLEKNANTSLFS
IFLGKQFLLDYLLFSYLTATEMTFSYYVDSIKNFLLTIRHLENVQQNVDFRTILQSRNFDLKYLLTQSWTQNVLEQSIFHVQLDKIIADIKQPQLSLKKI
PLVLFNGDNEVVSTYVPPEQASQTEQSFRIKNIFPNPVQEYSSKNVILFTNYPKNTKFLFNSPPPKTAAKSYKLPDTTDDINTETLSSPTIQRIPIKGLV
PKENEIVFLPEKNTAHTDSKETKTHLIDTFNILSQTKGEIKTFSTDFDQTISKLKHLYF
2059
Not Available
Not Available
01-10-1996
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.
3.4.19.12 , 3.4.22.-
Virion tegument . Host cytoplasm . Host nucleus . Note=Tightly associated with the capsid. .
DOMAIN 3 220 Peptidase C76.
Not Available
Predicted/Modelled
Not Available
♦ACT_SITE 23 23
♦ ACT_SITE 155 155
♦ ACT_SITE 157 157
♦ ACT_SITE 155 155
♦ ACT_SITE 157 157
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available