Results | viHumans

UniProt ID

P52357

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

HELI U77

Protein Name

DNA replication helicase (EC 3.6.4.-)

Organism Name

Human Herpesvirus 7 (strain JI) (HHV-7) (Human T Lymphotropic Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Roseolovirus> Human Betaherpesvirus 7> Human Herpesvirus 7 (strain JI) (HHV-7) (Human T Lymphotropic Virus)

RefSeq

NC_001716.2 ; AF037218.1

PubMed ID

8709220

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSLSSLFNGKYDTKFLLNMSSAAKVELIVEKVAALADACLETPLPTDWFRNILDPELEFNSNFEEIHSIGDEEFAQPLPFLPFRVLLITGTAGAGKTSSI
QTLAANSDCLITATTSIAAQNLSGLLNRTKSAQVKTIFKTFGFNSSHVSMNERISCSVTTLDSIADQQKHDLSTYWNVIADIAERALNAANGKTKVIPDL
CESSVIVIDEAGVILRHILHTVVFFYWFYNGLHKTQLYKNRVIPCIVCVGSPTQSGALISSFNPLTQNKDVKKGFDILSALICDDILSNYCKISENWVIF
VNNKRCTDVEFGEFLKHIEFGLPLKPELIEYVDRFVRPATYIRNPTNEIGMTRLFLSHYEVKSYFKVLHEQVELTNKDNLFTFPVYFIIQNKAFEDYKNE
ISNFTLEIEPWFKTNLHRLNTYSQFADQDLSKTIQIEEIVLDDGSVEETLITCHLKHIKHSSIGVTSRTKSSTVGFSGTYEKFVELLQSDLFIEKTACEY
SVHAYSFLTGLMYGGMYSFCLSEFTTSEVMTEIRKIKLPNIDFLQTMTAEVSLQTFDESDEYYDLHIAPTDEEMLASDPCPDPFFLKYKQLPLTNVLTFE
EISYLYTVFKEIFISRFAILQRHSKEMFGKSNLITYNRNNVSSKRCGEICSHVKSFYGMLTYAVPANNYTLEGYTYDNVIFLGTDKMLPPIIYKRGLPKI
VIKDEMGFISILDNNVSKLTDTVNGNSFHICTTIDYAIVSKVAMTVTKSQGLSIQRVALDFGNDPKNLKLSSIYVGMSRVVDPNNLIMNLNPLRLNYEND
NIIASHIVKALKNKDTMLIF
						

Length

820

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1996

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.

EC

3.6.4.-

Experimentally known GO terms

GO:0004386 ; GO:0005524 ; GO:0006260 ; GO:0042025

Subcellular Location

Host nucleus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available