Results | viHumans

UniProt ID

P52343

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

RIR1 P2LF2 U28[Gene ID: 1487905 ]

Protein Name

Ribonucleoside-diphosphate reductase large subunit-like protein

Organism Name

Human Herpesvirus 6A (strain Uganda-1102) (HHV-6 Variant A) (Human B Lymphotropic Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Roseolovirus> Human Betaherpesvirus 6A> Human Herpesvirus 6A (strain Uganda-1102) (HHV-6 Variant A) (Human B Lymphotropic Virus)

RefSeq

Not Available

PubMed ID

8289364 ; 7747482 ; 10573165 ; 18990579

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1487905

Reactome

Not Available

Sequence

							MKRKERRINKDYGYNRKCVCHYEASQKRFCYSQYSCASVLYERVRDIAKIIDRLDSGLDAWCLRDAIISVLRATHCVPRVDRMLGRWYLKTSVFYDFCPD
DLILSCPNVIMPNVLNFVKKYRDFIRSVLYKVSVSWKNQYMPGVLAASRFLEEISNSLNGVEESIPCIYLRMCATLTEIVLRIGYLREIYQENPYVMFEE
LAFSLFTQKWVLPFSCMTNLGLVEKANSTVFDVAIYNTCLYSLVDFTIVNGEHLFPALLNGSNISMNLTRYQQEAKNIFEILLSQIRVVERDTDKTVQLT
VYVEVWHVSALMWLDLYEALPQTSRVTFCLIIPGIFMDRYELKRAQWSLFHKNIAFELGKCDEITFSTKYLEFERTTDHAKITMSSFIEKICLCLKGGRM
GLIFRKNVYQYSMIPHVPLYCGGDFLDVLPVRDGINTCMRMLLNVVHFLGDEVSDELTEEIDFVRLQCKFFMFNELRRVVRKMVLVANAVIDYAVENKDF
LCEGIEDGRSLGICVTGLHSVFMTVGLSYAHPDARRLYRMICEHIYYTCVRTSVDCCMKGAEPCNLFDRSKYALGMLYFDHFDNVECTLPEELWTTLRKD
VLMHGVRNIHFTAGTAMQKEFDIINSSESFWPMEDNKILRRSNIKVVIGKDGLNDVTSVYSSELKSLYIPVYNNLLLNRFNKHQQYLKTVGYRVLNVDTN
LFTDKELDDLAVFKDGFSYHLNDLIEMYKSGLPFLDQGQANVFYFNDTVSLRLLLPLLYKAGFKVAMYKVLCNSEMYKHLDLSNPLPLIGKCSDGVVMHV
KNIL
						

Length

804

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1996

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.

EC

Not Available

Experimentally known GO terms

GO:0006260 ; GO:0019012 ; GO:0030430 ; GO:0055114

Subcellular Location

Virion . Host cytoplasm .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available