Results | viHumans

UniProt ID

P50641

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

RIR1 U28[Gene ID: 3289486 ]

Protein Name

Ribonucleoside-diphosphate reductase large subunit-like protein

Organism Name

Human Herpesvirus 7 (strain JI) (HHV-7) (Human T Lymphotropic Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Roseolovirus> Human Betaherpesvirus 7> Human Herpesvirus 7 (strain JI) (HHV-7) (Human T Lymphotropic Virus)

RefSeq

NC_001716.2 ; AF037218.1

PubMed ID

8709220 ; 10573165 ; 18990579

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:3289486

Reactome

Not Available

Sequence

							MDPNNKVSINKNMGLLRKCLCHDEYNKKRFCYSRFHHKTLLYKQLYEISKILRRLNSGLDMWCLRDAIISALGAMHDAPHVDRLLGQFYLKTNSASEFDS
ISLILESENILQKELIEFVRDSKVELEKILQAAIHVWRAKFSPGVLAASRFLDEISNSFNGIEENIPTIFLRISVTLASQIKKIEYLQKSFVSHKCPLVE
EILILLYKRVCMLPFPCMSNLGLVSEKKSVFDTVFHNVSNFSLEDFLDINSGFFLPAMLNGSYVSVNLTRYHYEAESLMELLLSQLQIVEKDTNKTTGLT
IYLEIWHLSLLMWLDFCEILPTTVQVKFCLILPEIFMERLKTENSYWSVFHKALAINLGLYDESDFTSKYLECERTAEHARIKTETLLDNICRCLRRGQM
GFIFRKNIHKYSMLPQIASYCLGNSMDVIPFEYGLNTAFRIALNLSYFVENVSEEQKSHTNIDMFHYRDKIFNLKKMRKTVTELVLIGNAVIDYALENRD
FLMDGIVNARSLAICVTGLHSALMSMNLPFNSQLGCQLYRIVCENIYYSSVRTSMNCCKKGAEPCSFFQRSKYAQGILHCDLYDNVEYTLPNVLWTNLRS
DIKKYGLRNLTFVSGSAMSKEFDLLNCSQSFCPIEGNKILKRSSIKVLHPNPVFHSDLSVYSTELQTLYIPVYNGLFLNRFKNHLEYLSSVNYDVSKVNK
NLFSEEEMQEMTIFLNAFDYSVNEMLNMYVGALPFTDHGQANVFFINKTENMRDILVCLYQNGFKTGIYQAVYKNQKCDGVNPSKKFDLLSGFSDGVVMS
TMHVFQ
						

Length

806

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1996

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.

EC

Not Available

Experimentally known GO terms

GO:0006260 ; GO:0019012 ; GO:0030430 ; GO:0055114

Subcellular Location

Virion . Host cytoplasm .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available