Results | viHumans

UniProt ID

P42927

Status

Reviewed

Host

Bos Taurus (Bovine) [TaxID: 9913]; Felis Catus (Cat) (Felis Silvestris Catus) [TaxID: 9685]; Homo Sapiens (Human) [TaxID: 9606]; Loxodonta Africana (African Elephant) [TaxID: 9785]; Microtus Agrestis (Short-tailed Field Vole) [TaxID: 29092]; Mus Musculus (Mouse) [TaxID: 10090]; Myodes Glareolus (Bank Vole) (Clethrionomys Glareolus) [TaxID: 447135]

Gene Name

SPI-1 CPXV217

Protein Name

Serine proteinase inhibitor 1 (Serp-1) (Serpin-1)

Organism Name

Cowpox Virus (strain Brighton Red) (CPV)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Cowpox Virus (CPV)> Cowpox Virus (strain Brighton Red) (CPV)

RefSeq

NC_003663.2 ; AF482758.2

PubMed ID

8009842 ;

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MDIFKELILKHTDENVLISPVSILSTLSILNHGAAGSTAEQLSKYIENKNTPKDDKDDNNDMDVDIPYCATLATANKIYCSDSIEFHASFLQKIKDDFQT
VNFNNANQTKELINEWVKTMTNGKINSLLTTPLPINTRMTVVSAVHFKAMWKYPFSKHLTYTDKFYISKNIVTSVDMMVSTKNDLQYVHINELFGGFSII
DIPYEGNSSMVIILPDDIEGLYNIEKHITDENFKKWCSKLSTKSIDLYMPKFKVEMTEPYNLVPILENLGLTNIFGYYSDFSKMCNETITVEKFLHKTFI
DVNEEYTEASAITGVFMTNFSMVYRTKVYINHPFMYMIKDNTGRILFIGKYCYPQ
						

Length

355

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-11-1995

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

This viral protein may be involved in the regulation of the complement cascade.

EC

Not Available

Experimentally known GO terms

GO:0004867 ; GO:0005615 ; GO:0030430

Subcellular Location

Host cytoplasm .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available