Reviewed
Homo Sapiens (Human) [TaxID: 9606]; Phlebotomus Perniciosus [TaxID: 13204]
L[Gene ID: 3077272 ]
RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)
Toscana Virus (Tos)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Bunyavirales> Phenuiviridae> Phlebovirus> Sandfly Fever Naples Phlebovirus> Toscana Virus (Tos)
Various pathway(s) in which protein is involved
Not Available
MERILKKQPAPVRALTIHPLRRYESSIYDTPIPAYVIKHSSDGVTIDIATSELADGQSGSTIQPFESVPAQNLTLFKHDFTFGHLADTTDKKFVEVFGVL
ENRADDSDFQSPDMIIETETGHVYVVEFTTTMGDANSADLAARNKIAKYEIACLNRSAIKPISLYIIAVHFNGVISNLDLSDEEVNEIVFRFRLARDIFE
ELREINPALFDSDETISRLEREVNSVMSAIQIDWDTTEKKFPSFRRELFENFRSKEVDDEYISKIIKRCTDEALRGIERDSLYTEDITNKERFELNSKRA
ASDIKNKMAEMMSYEFLRDTEDHKSTVQFPPWVTRTGPAGKDLEPLKSVSVEGSHPMCKIWNKVCTNASIEKIERMHDDPVLELEYAMSGSTERSVERNK
YHRTVLTLSPEEREYAAVLGVCGKRNANLGAVKEARVRSKKGFSIGHNTERVEEFLSDSCVEDLIPTEGLYNPLSEDKSLRLLAMGLHQPTLIHMDDETP
ETLDCHLKFLSSPIGSWLQMVSIVGAELSASVKQHVKPNQFIVKRLLDSAIFLLIKPTTSKGHIFVSLAVNKKFLHGELSKSSVFKQSIDAGDLLVTDFV
SFKLSKITNLCKALCVLEAASCFWAETYGFEPWKFVDQASAVKFLDAWFMIKLSLLTMLEDKATTEELQTMQRYVIMEGFVSLPEIPKPHKMLSKIPKVL
RSELQVFLTHRLFSTMQRISATPFQLHKVGGNIRWKGLFNPYSGNSIDELQTLISCCYNGYFKNKEEDTEPSALSAMYKKIIELEHLRPPTDTYLGYEDP
IDPKMHEFSRSYLKLLCNHAKTKLRKQYGRGVMNQIENSIVREVQSITLERLATLKATSNFDDSWYTFKDVKDKNYTRDKLLVKMTQFAHRGKTLAIEVF
EECMSRIEEKGCMEICLFKKQQHGGLREIYVMGADERIVQSVIEAIARAIGRFFDSDTLCNPSNKIRIPETHGQRAKRRCGRSVWTCATSDDARKWNQGH
YVTKFALMLCEFTPQEWWPLIIRGCSMFTNKFMMMNLDFLRIIDSHKELQIEDEFVSKLFKAYHGESVEPWISQGCTYLKTSTGMMQGILHFTSSLLHSL
HQEFVKTTAIQLFTLKLGSDASSKVVCDMMQGSDDSSMIISFPSYNEKIKMRYKLVAAMCFRIKKSLGIYIGIYPSEKSTPNTDFVMEYNSEFFFHSQHV
RPTIRWIAASCSLPEVETLVASKEEAANLLTAITEGGGSFSLAAMIQHCQSSIHYMLMGLGVSALFSEFSKAISKWLDPGLGFFLFDNPYSAGLSGFKYN
LYRAIMNSSLKSIYSFFMKRVKGGSQRTDGIISESCSVSPGGAIVMSSTLRWGSVEKFKRLRNRLNIPETWKEMINESPEVLYRAPQTGTEIMLRIAEKV
HSPGVVSSLSTGNAVCKVMASSVYFLSACIFEDAGSQEYKVVNNDKYSLMQKIIAFDQIGCNDEISQEDLLFLFPNLAEFEAFDSIIYDKGRFNVIPRAS
QREATQTRIVVFEHHSSARVAPEKLVSDKWFGTRKSKIGSPGFRQEWDRLKAIVRWLRDTPEETLDSSPFSNHIQIRNFFARMEGRPRVIKVTGAPVKRD
LGMSKIAMAIRDNFCKTGFLQGLEDEVGHSRAMQVEKIKHYLFSVLMGPYSEEAKLEYVVKILKEEPQVILNYNDKRSRANIISLLQRFIKSEIGIATLI
EDMKAGVFGAFVKAQQFSQSSVNNKYYGRGIWKGVMDGYQVQIDIDGKEGMPSHLSGITISNCSKTWILTQSLKAWCEDMQVYNNTDVSKANPKANYWMY
GFKMYGSSYPYGCPIYLVRHDITNLGLLHDDDIDIKVRRNTINLFVRSKDKRPRDLHILSYTPSDSDISSVSSKHIMEDEYFVYKGAFSVEPTRSWMLCQ
PLPWSFVRPVLQVATGSRRSPRQLDLERLREIIRLCTESSIRNKVGTVYGQNRPEKFIEAEPIDMSEMFDMMLDEGMDDAFEELADYLTVEEDPDYMDEV
SFDDDSLNLFGPAHYKELQSLTVLAHPLMDDFVTRLVGKMGRPQIRRLLEKNVTTRDLRELSELLFMALDRDPSQIREELILGDSPTEVPDDLLG
ENRADDSDFQSPDMIIETETGHVYVVEFTTTMGDANSADLAARNKIAKYEIACLNRSAIKPISLYIIAVHFNGVISNLDLSDEEVNEIVFRFRLARDIFE
ELREINPALFDSDETISRLEREVNSVMSAIQIDWDTTEKKFPSFRRELFENFRSKEVDDEYISKIIKRCTDEALRGIERDSLYTEDITNKERFELNSKRA
ASDIKNKMAEMMSYEFLRDTEDHKSTVQFPPWVTRTGPAGKDLEPLKSVSVEGSHPMCKIWNKVCTNASIEKIERMHDDPVLELEYAMSGSTERSVERNK
YHRTVLTLSPEEREYAAVLGVCGKRNANLGAVKEARVRSKKGFSIGHNTERVEEFLSDSCVEDLIPTEGLYNPLSEDKSLRLLAMGLHQPTLIHMDDETP
ETLDCHLKFLSSPIGSWLQMVSIVGAELSASVKQHVKPNQFIVKRLLDSAIFLLIKPTTSKGHIFVSLAVNKKFLHGELSKSSVFKQSIDAGDLLVTDFV
SFKLSKITNLCKALCVLEAASCFWAETYGFEPWKFVDQASAVKFLDAWFMIKLSLLTMLEDKATTEELQTMQRYVIMEGFVSLPEIPKPHKMLSKIPKVL
RSELQVFLTHRLFSTMQRISATPFQLHKVGGNIRWKGLFNPYSGNSIDELQTLISCCYNGYFKNKEEDTEPSALSAMYKKIIELEHLRPPTDTYLGYEDP
IDPKMHEFSRSYLKLLCNHAKTKLRKQYGRGVMNQIENSIVREVQSITLERLATLKATSNFDDSWYTFKDVKDKNYTRDKLLVKMTQFAHRGKTLAIEVF
EECMSRIEEKGCMEICLFKKQQHGGLREIYVMGADERIVQSVIEAIARAIGRFFDSDTLCNPSNKIRIPETHGQRAKRRCGRSVWTCATSDDARKWNQGH
YVTKFALMLCEFTPQEWWPLIIRGCSMFTNKFMMMNLDFLRIIDSHKELQIEDEFVSKLFKAYHGESVEPWISQGCTYLKTSTGMMQGILHFTSSLLHSL
HQEFVKTTAIQLFTLKLGSDASSKVVCDMMQGSDDSSMIISFPSYNEKIKMRYKLVAAMCFRIKKSLGIYIGIYPSEKSTPNTDFVMEYNSEFFFHSQHV
RPTIRWIAASCSLPEVETLVASKEEAANLLTAITEGGGSFSLAAMIQHCQSSIHYMLMGLGVSALFSEFSKAISKWLDPGLGFFLFDNPYSAGLSGFKYN
LYRAIMNSSLKSIYSFFMKRVKGGSQRTDGIISESCSVSPGGAIVMSSTLRWGSVEKFKRLRNRLNIPETWKEMINESPEVLYRAPQTGTEIMLRIAEKV
HSPGVVSSLSTGNAVCKVMASSVYFLSACIFEDAGSQEYKVVNNDKYSLMQKIIAFDQIGCNDEISQEDLLFLFPNLAEFEAFDSIIYDKGRFNVIPRAS
QREATQTRIVVFEHHSSARVAPEKLVSDKWFGTRKSKIGSPGFRQEWDRLKAIVRWLRDTPEETLDSSPFSNHIQIRNFFARMEGRPRVIKVTGAPVKRD
LGMSKIAMAIRDNFCKTGFLQGLEDEVGHSRAMQVEKIKHYLFSVLMGPYSEEAKLEYVVKILKEEPQVILNYNDKRSRANIISLLQRFIKSEIGIATLI
EDMKAGVFGAFVKAQQFSQSSVNNKYYGRGIWKGVMDGYQVQIDIDGKEGMPSHLSGITISNCSKTWILTQSLKAWCEDMQVYNNTDVSKANPKANYWMY
GFKMYGSSYPYGCPIYLVRHDITNLGLLHDDDIDIKVRRNTINLFVRSKDKRPRDLHILSYTPSDSDISSVSSKHIMEDEYFVYKGAFSVEPTRSWMLCQ
PLPWSFVRPVLQVATGSRRSPRQLDLERLREIIRLCTESSIRNKVGTVYGQNRPEKFIEAEPIDMSEMFDMMLDEGMDDAFEELADYLTVEEDPDYMDEV
SFDDDSLNLFGPAHYKELQSLTVLAHPLMDDFVTRLVGKMGRPQIRRLLEKNVTTRDLRELSELLFMALDRDPSQIREELILGDSPTEVPDDLLG
2095
Not Available
Not Available
01-10-1994
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Not Available
2.7.7.48
Not Available
DOMAIN 976 1167 RdRp catalytic.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available