Results | viHumans

UniProt ID

P36794

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

E2

Protein Name

Regulatory protein E2

Organism Name

Human Papillomavirus Type 45

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Papillomaviridae> Alphapapillomavirus> Alphapapillomavirus 7> Human Papillomavirus Type 45

RefSeq

Not Available

PubMed ID

8205838

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MKMQTPKESLSERLSALQDKILDHYENDSKDINSQISYWQLIRLENAILFTAREHGITKLNHQVVPPINISKSKAHKAIELQMALKGLAQSKYNNEEWTL
QDTCEELWNTEPSQCFKKGGKTVHVYFDGNKDNCMNYVVWDSIYYITETGIWDKTAACVSYWGVYYIKDGDTTYYVQFKSECEKYGNSNTWEVQYGGNVI
DCNDSMCSTSDDTVSATQIVRQLQHASTSTPKTASVGTPKPHIQTPATKRPRQCGLTEQHHGRVNTHVHNPLLCSSTSNNKRRKVCSGNTTPIIHLKGDK
NSLKCLRYRLRKYADHYSEISSTWHWTGCNKNTGILTVTYNSEVQRNTFLDVVTIPNSVQISVGYMTI
						

Length

368

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-06-1994

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0003700 ; GO:0006260 ; GO:0006275 ; GO:0006351 ;
GO:0016032 ; GO:0042025

Subcellular Location

Host nucleus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available