Results | viHumans

UniProt ID

P36711

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

L5[Gene ID: 1460847 ]

Protein Name

Fiber protein (SPIKE) (Protein IV)

Organism Name

Human Adenovirus A Serotype 12 (HAdV-12) (Human Adenovirus 12)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus A> Human Adenovirus A Serotype 12 (HAdV-12) (Human Adenovirus 12)

RefSeq

NC_001460.1 ; X73487.1

PubMed ID

8254750 ; 10567268 ; 16160140

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1460847

Reactome

Not Available

Sequence

							MKRSRTQYAEETEENDDFNPVYPFDPFDTSDVPFVTPPFTSSNGLQEKPPGVLALNYKDPIVTENGTLTLKLGDGIKLNAQGQLTASNNINVLEPLTNTS
QGLKLSWSAPLAVKASALTLNTRAPLTTTDESLALITAPPITVESSRLGLATIAPLSLDGGGNLGLNLSAPLDVSNNNLHLTTETPLVVNSSGALSVATA
DPISVRNNALTLPTADPLMVSSDGLGISVTSPITVINGSLALSTTAPLNSTGSTLSLSVANPLTISQDTLTVSTGNGLQVSGSQLVTRIGDGLTFDNGVM
KVNVAGGMRTSGGRIILDVNYPFDASNNLSLRRGLGLIYNQSTNWNLTTDISTEKGLMFSGNQIALNAGQGLTFNNGQLRVKLGAGLIFDSNNNIALGSS
SNTPYDPLTLWTTPDPPPNCSLIQELDAKLTLCLTKNGSIVNGIVSLVGVKGNLLNIQSTTTTVGVHLVFDEQGRLITSTPTALVPQASWGYRQGQSVST
NTVTNGLGFMPNVSAYPRPNASEAKSQMVSLTYLQGDTSKPITMKVAFNGITSLNGYSLTFMWSGLSNYINQPFSTPSCSFSYITQE
						

Length

587

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-06-1994

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0007155 ; GO:0019028 ; GO:0042025 ; GO:0046718 ; GO:0098671

Subcellular Location

Virion . Host nucleus . Note=Anchored to the pentons, protrudes from the virion surface. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

X-ray crystallography (4)

Experimetally known structure

1KAC 1NOB 1P69 1P6A

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available