Reviewed
Homo Sapiens (Human) [TaxID: 9606]; Rattus Norvegicus (Rat) [TaxID: 10116]
Not Available
RNA-directed RNA polymerase (EC 2.7.7.48) (Protein VP1)
Rotavirus B (isolate RVB/Rat/United States/IDIR/1984/G1P[X]) (RV-B) (Rotavirus B (isolate Infectious Diarrhea Of Infant Rats))
Viruses> DsRNA Viruses> Reoviridae> Sedoreovirinae> Rotavirus> Rotavirus B> Unclassified Rotavirus B> Rotavirus B (isolate RVB/Rat/United States/IDIR/1984/G1P[X]) (RV-B) (Rotavirus B (isolate Infectious Diarrhea Of Infant Rats))
KU562873.1 ; KU562874.1 ; KU562875.1 ; KU562876.1 ; KU562877.1 ; KU562878.1 ; KU562879.1 ;
KU562880.1 ; KU562881.1 ; KU562882.1 ; KU562883.1
KU562880.1 ; KU562881.1 ; KU562882.1 ; KU562883.1
Various pathway(s) in which protein is involved
Not Available
Not Available
MDSFQFFEWLLRDIERNLLYTSLVYTNPKIAIVRYEPSENAKLWRSKELNTDSPNELLLTLKKTLDECSTLDEKIETLLRIRYFTVYVGDKSDKRNIIRS
WLSTTINRLNVEEYASIQEIELQAKQWRAENAKSLRPYHYNIPINEYLRDNEIEVLDTGDNRWKSDTLQGLLPNFYHRTHTLIGAILFAVTSRLEIYSYE
QKKALRYLLRTIEKCYNEGYLEMSRDRKWSHTLPELRTLTFRLYNSKVIHAACAMISLVHANPIDYEFLCQVVAVYQIIPANAAKLLSTPMTLYVGVATF
SSNQVASTGNASECAPLQIENNIYVSEAQKKEWAESFKSDPLNKSRMLKLMNENLNTTLDKFSLIFNCFSSTFHVGHRIDNAQDAITDQVTATYTSNVNR
EMYDSYYYKLKQMLKEEIVQYVEDHVAKQYKDVTAESLSALANSSNGFSKEVKFIDRNIKTTKKILHLDNDLITNDYSDLSKALSHGIPMGTRNVPARQT
RGIFILPWQVAAVQHTIAESLYKRAKKGAYQGSFAEAYTAKTASLTYGVLAEDTSKATKIILYTDVSQWDASQHNTEPYRSAWINAIREARAELKWRYDD
EPKVLEMNVLDSMIKIQEYLLNSNLVVASPGSQRPTKIIRYHGVASGEKTTKIGNSFANVALIETVLDFAKTDIPDLEISHLRVDGDDNVVSINTSCTID
RLQRIIKEKYSSLNARVKALASYTGLEMAKRFIICGKIFERGAIPIFTAERPYGTDVSIQSMCGSSIYSSAVNAYRGFGDAYFSFMQDVLVPPSASTRIT
GRLRVLMSPVTLYATGPLSFEITPQGLGGRCRFFTQSAKLFTLFKMLTQTAAVSITPDEIKKYAETVQFKKRTEVMIASMQRKLLVPAKALARIIVDKEQ
QKTLGVPNVQSQKNRSQVSKAIEILGVPERNDIVAKGYYPEELYSLIISHSVVVYTSHSTPISIYRVNCEPVELLRSQLGIRIADSKPIAKPTNHLYDIV
SGLSPIKISPSDLLTQAKKYDLSTYKGKRDYLSDLGLVGNTLKTYLASKMLFRDLLMSKYDDLYSTPGFGATQLTTIPLDVTSAEKVFSIRLGLPPHLYE
VVMLLLLYEYIHYVFSCKRTFTAQMHAISQEQSAVITKNIILMLDNIQLDQVSFSDDAW
WLSTTINRLNVEEYASIQEIELQAKQWRAENAKSLRPYHYNIPINEYLRDNEIEVLDTGDNRWKSDTLQGLLPNFYHRTHTLIGAILFAVTSRLEIYSYE
QKKALRYLLRTIEKCYNEGYLEMSRDRKWSHTLPELRTLTFRLYNSKVIHAACAMISLVHANPIDYEFLCQVVAVYQIIPANAAKLLSTPMTLYVGVATF
SSNQVASTGNASECAPLQIENNIYVSEAQKKEWAESFKSDPLNKSRMLKLMNENLNTTLDKFSLIFNCFSSTFHVGHRIDNAQDAITDQVTATYTSNVNR
EMYDSYYYKLKQMLKEEIVQYVEDHVAKQYKDVTAESLSALANSSNGFSKEVKFIDRNIKTTKKILHLDNDLITNDYSDLSKALSHGIPMGTRNVPARQT
RGIFILPWQVAAVQHTIAESLYKRAKKGAYQGSFAEAYTAKTASLTYGVLAEDTSKATKIILYTDVSQWDASQHNTEPYRSAWINAIREARAELKWRYDD
EPKVLEMNVLDSMIKIQEYLLNSNLVVASPGSQRPTKIIRYHGVASGEKTTKIGNSFANVALIETVLDFAKTDIPDLEISHLRVDGDDNVVSINTSCTID
RLQRIIKEKYSSLNARVKALASYTGLEMAKRFIICGKIFERGAIPIFTAERPYGTDVSIQSMCGSSIYSSAVNAYRGFGDAYFSFMQDVLVPPSASTRIT
GRLRVLMSPVTLYATGPLSFEITPQGLGGRCRFFTQSAKLFTLFKMLTQTAAVSITPDEIKKYAETVQFKKRTEVMIASMQRKLLVPAKALARIIVDKEQ
QKTLGVPNVQSQKNRSQVSKAIEILGVPERNDIVAKGYYPEELYSLIISHSVVVYTSHSTPISIYRVNCEPVELLRSQLGIRIADSKPIAKPTNHLYDIV
SGLSPIKISPSDLLTQAKKYDLSTYKGKRDYLSDLGLVGNTLKTYLASKMLFRDLLMSKYDDLYSTPGFGATQLTTIPLDVTSAEKVFSIRLGLPPHLYE
VVMLLLLYEYIHYVFSCKRTFTAQMHAISQEQSAVITKNIILMLDNIQLDQVSFSDDAW
1159
Not Available
Not Available
01-06-1994
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
RNA-directed RNA polymerase that is involved in both transcription and genome replication. Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core. Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell. VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins. One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2. The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsDNA formation. To do so, the polymerase specifically recognizes conserved 3' sequence(s) in plus-strand RNA templates. Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription (By similarity).
2.7.7.48
Virion . Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity). .
DOMAIN 545 727 RdRp catalytic.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available