Results | viHumans

UniProt ID

P35774

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

L5

Protein Name

Fiber protein (SPIKE) (Protein IV)

Organism Name

Human Adenovirus B Serotype 11 (strain Slobiski) (HAdV-11) (Human Adenovirus 11P (strain Slobiski))

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus B> Human Adenovirus B2> Human Adenovirus 11> Human Adenovirus B Serotype 11 (strain Slobiski) (HAdV-11) (Human Adenovirus 11P (strain Slobiski))

RefSeq

NC_011202.1 ; AY163756.1

PubMed ID

8503168 ; 16160140

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MTKRVRLSDSFNPVYPYEDESTSQHPFINPGFISPNGFTQSPNGVLTLKCLTPLTTTGGSLQLKVGGGLTVDDTNGFLKENISATTPLVKTGHSIGLPLG
AGLGTNENKLCIKLGQGLTFNSNNICIDDNINTLWTGVNPTEANCQIMNSSESNDCKLILTLVKTGALVTAFVYVIGVSNNFNMLTTHRNINFTAELFFD
STGNLLTRLSSLKTPLNHKSGQNMATGAITNAKGFMPSTTAYPFNDNSREKENYIYGTCYYTASDRTAFPIDISVMLNRRAINDETSYCIRITWSWNTGD
APEVQTSATTLVTSPFTFYYIREDD
						

Length

325

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-06-1994

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface.

EC

Not Available

Experimentally known GO terms

GO:0007155 ; GO:0019028 ; GO:0042025 ; GO:0046718 ; GO:0098671

Subcellular Location

Virion . Host nucleus . Note=Anchored to the pentons, protrudes from the virion surface. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

X-ray crystallography (2)

Experimetally known structure

2O39 3EXV

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available