Results | viHumans

UniProt ID

P35423

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

Not Available

Protein Name

Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

Organism Name

Rotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) (Rotavirus A (strain DS1))

Taxonomic Lineage

Viruses> DsRNA Viruses> Reoviridae> Sedoreovirinae> Rotavirus> Rotavirus A> Rotavirus G2> Rotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) (Rotavirus A (strain DS1))

RefSeq

NC_011500.2 ; NC_011501.2 ; NC_011502.2 ; NC_011503.2 ; NC_011504.2 ; NC_011505.2 ; NC_011506.2 ;
NC_011507.2 ; NC_011508.2 ; NC_011509.2 ; NC_011510.2 ; NC_011511.2

PubMed ID

8395125 ; 18786998

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MATFKDACYQYKKLNKLNNAVLKLGANDVWRPSTLTKRKGWCLDCCQHTDLTYCQGCLIYHVCEWCSQYNRCFLDDDPHLLRMRTFRNEITKSDLENLIN
MYNTLFPINKKIVHKFANTIKQHKCRNEYSTQWYNHFLMPITLQSLSIELDGDIYYIFGYYDDMHKINQTPFSFTNLISKYDMLLLDSINFDRMAFLPLT
LQQEYALRYFSKSRFITERRKCIEILHFSDNILDNLHNPNFTLQVIRNCSNMSVEWNKACNIIRNISDYFDILKSSHTEFYNISPRCRMFTQYKLKIASK
LIKPNYVASNHNSLATEVHNCKWCSINNNSIVWNDFRIKNVYNDIFNFIRALVKSNLYVGHCSSEEKIYESIKEVLNVCKENEWNMLVTEMFNQLEPIKL
NENNYILLNYEINWNVMNVLINSIGKIPKILTLSDVILILRIIIYDWFDIRFMRNTPMTTFTVNKLKQLYEKDRTAEHDSRISDIE
						

Length

486

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-06-1994

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0030430 ; GO:0039548 ; GO:0039557 ; GO:0044163 ;
GO:0046872

Subcellular Location

Host cytoplasm, host cytoskeleton .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available