Results | viHumans

UniProt ID

P33871

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

C16L F12L[Gene ID: 1486572 ]

Protein Name

Protein F12

Organism Name

Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

RefSeq

NC_001611.1 ; X69198.1

PubMed ID

8109158 ; 8384129

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1486572

Reactome

Not Available

Sequence

							MLNRVQILMKTANNYETIEILRNYLRLYIILARNEEGHGILIYDDNIDSIMSMMNITRLEVIGLTTHCTKLRSSPPIPMSRLFMDEIDHESYYSPKTSDY
PLIDIIRKRSHEQGDIALALKRYCIENTDSISEINEWLSSKGLACYRFVKFNDYRKQMYRKFSKCTIVDSMIIGHIGHHYIWIKNLETYTRPEIDVLPFD
IKYISRDELWAQISSSLDQTHIKTITVSVYGAITDNGPMPYMISTYPGNTFVNFNSVKDLILNFLDWIKDIMTSTRTIILVGYMSNLFDIPLLTVYWPNN
CGWKIYNNILISSDGARVIWMDAYKFSCGLSLQDYCYHWGSKPESRPFDLIKKIDAKRNIKSWVKESMTSLKSLYEAFETQSGALEVLMSPCRMFSFSRI
EDMFLTSVINRVSKNTGMGMYYPTNDISSLFIESSICLDYIIVNNQKSNKYRIKSVLDIISSKQYPAGRPNYVKNGTKGKLYIALCKVTVPTNDHIPVVY
HDDDNTTTFITVLTSVDIETATRAGYSIVELGALQWDDNIPELKDCLLDSIKMIYDLNTVTTNNLLEQLIENINFNNSSIILLFYTFAISYCRAFIYSIM
ETIDPVYISQFSYKELYIRSSYKDINEVMSQMVKL
						

Length

635

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-02-1994

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Late protein that plays a role in intracellular enveloped virus (IEV) transport to the cell surface on microtubules. When absent, viral morphogenesis halts after the formation of IEV particles, and these are not transported to the cell periphery. Important for plaque formation, extracellular envelope virus (EEV) production and virulence (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0009405 ; GO:0016032 ; GO:0044174 ; GO:0055036

Subcellular Location

Virion membrane . Host endosome . Note=Associates with the membrane of IEV particles, but not intracellular mature virus (IMV), cell-associated enveloped virus (CEV) or EEV. Colocalizes with microtubules (By similarity). .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available