Results | viHumans

UniProt ID

P33831

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

SPI-3 C2L[Gene ID: 1486579 ]

Protein Name

Protein K2 (Serine proteinase inhibitor 3)

Organism Name

Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

RefSeq

NC_001611.1 ; X69198.1

PubMed ID

8384129

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1486579

Reactome

Not Available

Sequence

							MIVLLILSLACTAFTYRLQGFTNAGIVAYKNIQDGNEDDNIVFSPFGYSFSMFMSLLPASGNTKVELLKTMDLRKIDLGPAFTELISGLAKPKTSKYTYT
DLTYQSFVDNTVCIKPSYYQQYHRFGLYRLNFRRDAVNKINSIVERRSGMSNVVDSTMLDNNTLWAIINTIYFKGTWQYPFDITKTHNTSFTNKYGTKTV
PMMSVVTKLQGNTITIDDEEYDMVRLQYKDANISMYLAIGDNMTHFTDSIMAAKLDYWSSQLGNKVYNLKLPRFSIENKRDIKSIAEMMAPSMFNPDNAS
FKHMTRDPLYIYKMFQNAKIDVNEQGTVAEASTIMVATVRSSPEELEFNTPFVFIIRHDITGFILFMGKVESP
						

Length

373

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-02-1994

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Prevents cell to cell fusion via its interaction with A56 protein. The A56-K2 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0004867 ; GO:0005615 ; GO:0020002 ; GO:0055036

Subcellular Location

♦ Virion membrane
♦ Peripheral membrane protein . Host cell membrane
♦ Peripheral membrane protein
♦ Extracellular side . Note=Component of extracellular enveloped virus (EEV) but not intracellular mature virus (IMV). Anchored to the surface of the outermost membrane of EEV via its interaction with A56 protein (By similarity). .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available