Results | viHumans

UniProt ID

P33827

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

A18R A19R[Gene ID: 1486493 ]

Protein Name

Transcript termination protein A18 (EC 3.6.4.-) (56 kDa abortive late protein)

Organism Name

Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

RefSeq

NC_001611.1 ; X69198.1

PubMed ID

8264798 ; 10639322

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1486493

Reactome

Not Available

Sequence

							MSLLKMEYNLYAELKKITCGQSLSLFNEDGDFVEVEPGSLFKFLIPKGFYSSPSVKTSLVFETLTTTDNKITSINPTNAPKLYPLQHKVVSEVVSNMRKM
IKLKRPLYITLHLACGFGKTITTCYLMATHGRKTVICVPNKMLIHQWKTQVEAVGLEHKISIDGVSSLLKELKTQSPDVLIVVSRHLTNDAFCKYINKHY
DLFILDESHTYNLMNNTAVTRFLAYYPPMMCYFLTATPRPSNRIYCNSIINIAKLSDLKKTIYAVDSFFEPYSTDNIRHMIKRLDGPSNKYHIYTEKLLS
VDEPRNQLILNTLVEEFKSGTINRVLVITKLREHMVLFYKRLLDLFGPEVVFIGDAQNRRTPDMVKSIKELNRFIFVSTLFYSGTGLDIPSLDSLFICSA
VINNMQIEQLLGRVCRETELLDRTVYVFPNTSVKEIKYMIGNFVQRIISLSVDKLGFKQESYRKHQESDPTSVCTASSREERVLNRIFNSQNR
						

Length

493

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-02-1994

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

DNA helicase which seems to act as a postreplicative transcription termination factor. Involved in ATP-dependent release of nascent RNA. Forms a stable complex with single-stranded DNA, and to a lesser extent RNA (By similarity).

EC

3.6.4.-

Experimentally known GO terms

GO:0003677 ; GO:0004386 ; GO:0005524 ; GO:0006351 ; GO:0019012

Subcellular Location

Virion . Note=Localizes to the virion core. .

Domain(s)

DOMAIN 100 256 Helicase ATP-binding.

Motif(s)

MOTIF 206 209 DESH box.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available