Reviewed
Homo Sapiens (Human) [TaxID: 9606]
HA A56R J9R[Gene ID: 1486455 ]
Protein A56 (Hemagglutinin)
Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)
Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)
Various pathway(s) in which protein is involved
Not Available
MTRLSILLLLISLVYSTPYPQTQISKKIGDDATLSCSRNNINDYVVMSAWYKEPNSIILLAAKSDVLYFDNYTKDKISYDSPYDDLVTTITIKSLTAKDA
GTYVCAFFMTSTTNDTDKVDYEEYSTELIVNTDSESTIDIILSGSSHSPETSSEKPDYINNFNCSLVFEIATPGPITDNVENHTDTVTYTSDIINTVSTS
SRESTTVKTSGPITNKEDHTVTDTVSYTTVSTSSEIVTTKSTANDAHNDNEPSTVSPTTVKNITKSIGKYSTKDYVKVFGIAALIILSAVAIFCITYYIC
NKRSRKYKTENKV
GTYVCAFFMTSTTNDTDKVDYEEYSTELIVNTDSESTIDIILSGSSHSPETSSEKPDYINNFNCSLVFEIATPGPITDNVENHTDTVTYTSDIINTVSTS
SRESTTVKTSGPITNKEDHTVTDTVSYTTVSTSSEIVTTKSTANDAHNDNEPSTVSPTTVKNITKSIGKYSTKDYVKVFGIAALIILSAVAIFCITYYIC
NKRSRKYKTENKV
313
Not Available
Not Available
01-02-1994
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Prevents cell to cell fusion by interacting with and directing the viral K2 protein on the host plasma membrane. The A56-K2 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation. Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack (By similarity).
Not Available
♦ Virion membrane
♦ Single-pass type I membrane protein . Host membrane
♦ Single-pass type I membrane protein . Note=Component of extracellular enveloped virus (EEV) but not intracellular mature virus (IMV). Component of the outermost membrane of EEV.
♦ Single-pass type I membrane protein . Host membrane
♦ Single-pass type I membrane protein . Note=Component of extracellular enveloped virus (EEV) but not intracellular mature virus (IMV). Component of the outermost membrane of EEV.
DOMAIN 18 121 Ig-like V-type.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available