Results | viHumans

UniProt ID

P33071

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

D10R[Gene ID: 1486416 ]

Protein Name

mRNA-decapping protein D10 (EC 3.1.3.-)

Organism Name

Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

RefSeq

NC_001611.1 ; X69198.1

PubMed ID

8383392 ; 8384129

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1486416

Reactome

Not Available

Sequence

							MNFYRSSIISQIIKYNRRLAKSIICEDDSQIITLTAFVNQCLWCHKRVSVSAILLTTDNKILVCNRRDSFLYSEIIRTRNMSRKKRLFLNYSNYLNKQER
SILSSFFSLDPATIDNDRIDAIYPGGILKRGENVPECLSREIKEEVNIDNSFVFIDTRFFIHGIIEDTIINKFFEVIFFVGRISLTSDQIIDTFKSNHEI
KDLIFLDPNSGNGLQYEIAKYALDTAKLKCYGHRGCYYESLKKLTEDD
						

Length

248

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1993

Protein Existence

Evidence at transcript level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Decapping enzyme required for the removal of the 5'-end m7GpppN cap tethered to viral and host mRNAs to allow their decay in cells. May therefore accelerate viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins. Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis (By similarity).

EC

3.1.3.-

Experimentally known GO terms

GO:0016791 ; GO:0046872

Subcellular Location

Not Available

Domain(s)

DOMAIN 45 227 Nudix hydrolase.

Motif(s)

MOTIF 126 147 Nudix box.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

ACT_SITE 141 141 Nucleophile.

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available