Results | viHumans

UniProt ID

P33062

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

H5R[Gene ID: 1486443 ]

Protein Name

Late transcription elongation factor H5 (Viral late gene transcription factor 4) (VLTF-4)

Organism Name

Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

RefSeq

NC_001611.1 ; X69198.1

PubMed ID

8383392 ; 8384129

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1486443

Reactome

Not Available

Sequence

							MAWSITNKADTSSFTKMAEIRAHLRNSAENKDKNDDIFPEDVIIPSTKPKTKRATTPRKPAATKRSTKKDKEKEEVEEEEVVIEEYHQTTEENSPPPSSS
PGVGNIVESVTAVELDDSNGDDDNDNDNDDNEPMVQVEAGKVNHSARSDLSDLKVATDNIVKDLKKIITRISAVSTVLEDVQAAGISRQFTSMTKSITTL
SDLVTEGKSKVVRKKVKTCKK
						

Length

221

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1993

Protein Existence

Evidence at transcript level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Involved in the co-transcriptional or post-transcriptional endoribonucleolytic cleavage that generates sequence-homogeneous 3' ends during late transcription. Involved in postreplicative transcription elongation on intermediate and late genes (Probable). Also involved in DNA replication and in multiple steps of virion morphogenesis. Required both for inclusion of virosoplasm into crescents as well as for maturation of immature virions (IV) into mature virions (MV) (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0003746 ; GO:0006351 ; GO:0006355 ; GO:0019031 ; GO:0030430

Subcellular Location

Virion . Host cytoplasm . Note=Early during viral infection, diffusely localizes within the cytoplasm. Following DNA replication, localizes specifically to virus factories (By similarity). .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available