Results | viHumans

UniProt ID

P33051

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

NPH2 I8R[Gene ID: 1486463 ]

Protein Name

RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside triphosphate phosphohydrolase II) (NPH II) (RNA helicase I8)

Organism Name

Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

RefSeq

NC_001611.1 ; X69198.1

PubMed ID

8109158 ; 8383392 ; 8264798 ; 10639322

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1486463

Reactome

Not Available

Sequence

							MEKNLPDIFFFPNCVNVFSYKYSQDEFSNMSNMERDSFSLAVFPVIKHRWHNAHVVKHKGIYKVSTEAHGKKVSPPSLGKPSHINLTAKQYIYSEHTISF
ECYSFLKCITNAEINSFDEYILRGLLEAGNSLQIFSNSVGKRTDTIGVLGNKYPFSKIPLASLTPKAQREIFSAWISHRPVVLTGGTGVGKTSQVPKLLL
WFNYLFGGFSTLDKITDFHERPVILSLPRIALVRLHSNTILKSLGFKVLDGSPISLRYGSIPEELINKQPKKYGIVFSTHKLSLTKLFSYGTLIIDEVHE
HDQIGDIIIAVARKHHTKIDSMFLMTATLEDDRERLKVFLPNPAFIHIPGDTLFKISEVFIHNKINPSSRMAYIEEEKRNLVTAIQMYTPPDGSSGIVFV
ASVAQCHEYKSYLEKRLPYDMYIIHGKVLEIDKILEKVYSSPNVSIIISAPYLESSVTIHNVTHIYDMGRVFVPAPFGGSQQFISKSMRDQRKGRVGRVN
PGTYVYFYDLSYMKSIQRINSEFLHNYILYANKFNLTLPEDLFIIPTNLDILWRTKEYIDSFDISTETWNKLLSNYYMKMIEYAKLYVLSPILAEELDNF
ERTGELTSIVQEAILSLNLRIKILNFKHKDNDTYIHFCKILFGVYNGTNATIYYHRPLTGYMNMISDTIFVPVDNN
						

Length

676

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1993

Protein Existence

Evidence at transcript level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs and plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase. Might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm. Required for replication and propagation of viral particles (By similarity).

EC

3.6.4.13

Experimentally known GO terms

GO:0003676 ; GO:0004386 ; GO:0005524 ; GO:0006351 ; GO:0019012

Subcellular Location

Virion. Note=Localizes to the virion core. .

Domain(s)

♦DOMAIN 172 347 Helicase ATP-binding.
♦ DOMAIN 366 542 Helicase C-terminal.

Motif(s)

MOTIF 296 299 DEXH box.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available