Results | viHumans

UniProt ID

P32991

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

G1L[Gene ID: 1486429 ]

Protein Name

Metalloendopeptidase G1 (EC 3.4.24.-)

Organism Name

Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

RefSeq

NC_001611.1 ; X69198.1

PubMed ID

8109158 ; 8383392 ; 8384129 ; 8264798 ; 10639322

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1486429

Reactome

Not Available

Sequence

							MIVLPNKVRIFINDRMKKDIYLGISNFGFENDIDEILGIAHLLEHLLISFDSTIFLANASTSRSYMSFWCKSINSATESDAIRTLVSWFFSNGKLKDNFS
LSSIRFHIKELENEYYFRNEVFHCMDILTFLSGGDLYNGGRIDMIDNLNIVRDMLVNRMQRISGSNIVIFVKRLGPGTLDFFNQTFGSLPACPEIIPSSI
PVSTNGKIVMTPSPFYTVMVKINPTLDNILGILYLYETYHLIDYETIGNQLYLTVSFIDETEYESFLRGEAILQISQCQRINMNYSDDYMMNIYLNFPWL
SHDLYDYITRINDDSKSILISLTNEIYTSIINRDIIVIYPNFSKAMCNTRDTQQHPIVVLDATNDGLIKKPYRSIPLMKRLTSNEIFIRYGDASLMDMIT
LSLSKQDISLKRNAEGIRVKHSFSADDIQAIMESDSFLKYSRSKPAAMYQYIFLSFFASGNSIDDILTNRDSTLEFSKKTKSKILFGRNARYDVTTKSSF
VCGIVRGKLLDKTSLVEMMWDLKKKGLIYSMEFTNLLSKNTFYLFTFTIYTDEVYDYLNTNKLFSAKCLVISTKGDVENFSSLKKDVVIRV
						

Length

591

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1993

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Probably involved in maturation of some viral proteins by processing them preferentially at Ala-Gly-|-Ser/Thr/Lys motifs. Does not seem to be responsible for the cleavage of major core proteins (By similarity).

EC

3.4.24.-

Experimentally known GO terms

GO:0004222 ; GO:0008270 ; GO:0019012 ; GO:0019058

Subcellular Location

Virion . Note=Localizes to the virion core. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

ACT_SITE 44 44

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available