Results | viHumans

UniProt ID

P32540

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]; Mus Musculus (Mouse) [TaxID: 10090]; Oryctolagus Cuniculus (Rabbit) [TaxID: 9986]

Gene Name

Not Available

Protein Name

♦Genome polyprotein [Cleaved into: Protein VP0 (VP4-VP2)
♦ Protein VP4 (P1A) (Rho) (Virion protein 4)
♦ Protein VP2 (Beta) (P1B) (Virion protein 2)
♦ Protein VP3 (Gamma) (P1C) (Virion protein 3)
♦ Protein VP1 (Alpha) (P1D) (Virion protein 1)] (Fragment)

Organism Name

Mengo Encephalomyocarditis Virus (strain 37A)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Picornavirales> Picornaviridae> Cardiovirus> Cardiovirus A> Encephalomyocarditis Virus> Mengo Encephalomyocarditis Virus> Mengo Encephalomyocarditis Virus (strain 37A)

RefSeq

Not Available

PubMed ID

1326807

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MATTMEQEICAHSMTFEECPKCSALQYRNGFYLLKYDEEWYPEELLTDGEDDVFDPDLDIEVVFETQGNSTSSDKNNSSSEGNEGVIINNFYSNQYQNSI
DLSANATGSDPPKTYGQFSNLLSGAVNAFSNMLPLLADQNTEEMENLSDRVSQDTAGNTVTNTQSTVGRLVGYGTVHDGEHPASCADTASEKILAVERYY
TFKVNDWTSTQKPFEYIRIPLPHVLSGEDGGVFGAALRRHYLVKTGWRVQVQCNASQFHAGSLLVFMAPEYPTLDVFAMDNKWSKDNLPNGTRTQANRKG
PFAMDHQNFWQWTLYPHQFLNLRTNTTVDLEVPYVNIAPTSSWTQHASWTLVIAVVAPLTYSTGASTSLDITASIQPVRPVFNGLRHEVLSRQSPIPVTI
REHAGTWYSTLPDSTVPIYGKTPVAPANYMVGEYKDFLEIAQIPTFIGNKVPNAVPYIEASNTAVKTQPLAVYQVTLSCSCLANTFLAALSRNFAQYRGS
LVYTFVFTGTAMMKGKFLIAYTPPGAGKPTSRDQAMQATYAIWDLGLNSSYSFTVPFISPTHFRMVGTDLVNITNADGWVTVWQLTPLTYPPGCPTSAKI
LTMVSAGKDFSLKMPISPAPWSPQGVENAEKGVTENTDATADFVAQPVYLPENQTKVAFFYDRSSPIGAFTVKSGSLESGFAPFSNQACPNSVILTPGPQ
FDPAYDQLRPQRLTEIWGNGNEETSEVFPLKTKQDYSFCLFSPFVYYKCDLEVTLSPHTSGNHGLLVRWCPTGTPNKPTTQVLHEVSSLSEGRTPQVYSA
GPGTSNQISFVVPYNSPLSVLPAVWYNGHKRFDNTGYLGIAPNSDFGTLFFAGTKPDIKFTVYLRYKNMRVFCPRPTVFFPWPTSGDKIDMTPRAGVLML
E
						

Length

901

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1993

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

♦Capsid proteins VP1, VP2, VP3 and VP4 form a closed capsid enclosing the viral positive strand RNA genome. VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes (By similarity).
♦ Protein VP0: VP0 precursor is a component of immature procapsids.

EC

Not Available

Experimentally known GO terms

GO:0005198 ; GO:0019030 ; GO:0019062 ; GO:0030430 ; GO:0046718

Subcellular Location

♦ Protein VP2: Virion. Host cytoplasm .
♦ Protein VP3: Virion. Host cytoplasm .
♦ Protein VP1: Virion. Host cytoplasm .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

NMR spectroscopy (1)

Experimetally known structure

2BAI

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available