Reviewed
Apodemus Agrarius (Eurasian Field Mouse) [TaxID: 39030]; Homo Sapiens (Human) [TaxID: 9606]
GP
♦Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1)
♦ Glycoprotein C (Gc) (Glycoprotein G2)]
♦ Glycoprotein C (Gc) (Glycoprotein G2)]
Hantaan Virus (strain B-1) (Korean Hemorrhagic Fever Virus)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Bunyavirales> Hantaviridae> Orthohantavirus> Hantaan Orthohantavirus> Hantaan Virus (strain B-1) (Korean Hemorrhagic Fever Virus)
Not Available
Various pathway(s) in which protein is involved
Not Available
Not Available
MWSLLLLAALVGQGFALKNVFDMRIQCPHSVNFGETSVSGYTELPPLSLQEAEQLVPESSCNMDNHQSLSTINKLTKVIWRKKANQESANQNSFEVVESE
VSFKGLCMLKHRMVEESYRNRRSVIYYDLAGNSTFCKPTVYMIVPIHACNMMKSCLIGLGPYRIQVVYERTYCTTGILTEGKCFVPDKAVVSALKRGMYA
IASIETICFFIHQKWNKYKIVTAITSAMGSKCNNTDTKVQGYYICIIGGNSAPVYAPAGEDFRAMEVFSGIITSPHGEDHDLPGEEIATYHISGQIEAKI
PHTVSSKNLRLAAFAGIPSYSSTSILAASEDGRFIFSPGLFPNLNQSVCDNNALPLIWRGLIDLTGYYEAVHPCNVFCVLSGPGASCEAFSEGGIFNITS
PMCLVSKQNRFRAAEQQISFVCQRVDMDIIVYCNGQKKTILTKTLVIGQCIYTITSLFSLLPGVAHSIAIELCVPGFHGWATAALLITFCFGWVLIPACT
LAILLVLKFFANILHTSNQENRFKAILRKIKEEFEKRKGSMVCEICKYECETLKELKAHNLSCVQGECPYCFTHCEPTETAIQAHYKVCQATHRFREDLK
KTVTPQNIGPGCYRTLNLFRYKSRCYILTMWTLLLIIESILWAASAAEIPLVPLWTDNAHGVGSVPMHTDLELDFSLPSSSKYTYKRHLTNPVNDQQSVS
LHIEIESQGIGADVHHLGHWYDARLNLKTSFHCYGACTKYQYPWHTAKCHFEKDYEYENSWACNPPDCPGVGTGCTACGLYLDQLKPVGTAFKIISVRYS
RKVCVQFGEEHLCKTIDMNDCFVTRHAKICIIGTVSKFSQGDTLLFLGPMEGGGIIFKHWCTSTCHFGDPRDVMGPKDKPFICPEFPGQFRKKCNFATTP
VCEYDGNIISGYKKVLATIDSFQSFNTSNIHFTDERIEWRDPDGMLRDHINIVISKDIDFENLAENPCKVGLQAANIEGAWGSGVGFTLTCQVSLTECPT
FLTSIKACDMAICYGAESVTLSRGQNTVKITGKGGHSGSSFKCCHGKECSSTGLQASAPHLDKVNGISELENEKVYDDGAPECGVTCWFKKSGEWVMGII
NGNWVVLIVLCVLLLFSLILLSILCPVRKHKKS
VSFKGLCMLKHRMVEESYRNRRSVIYYDLAGNSTFCKPTVYMIVPIHACNMMKSCLIGLGPYRIQVVYERTYCTTGILTEGKCFVPDKAVVSALKRGMYA
IASIETICFFIHQKWNKYKIVTAITSAMGSKCNNTDTKVQGYYICIIGGNSAPVYAPAGEDFRAMEVFSGIITSPHGEDHDLPGEEIATYHISGQIEAKI
PHTVSSKNLRLAAFAGIPSYSSTSILAASEDGRFIFSPGLFPNLNQSVCDNNALPLIWRGLIDLTGYYEAVHPCNVFCVLSGPGASCEAFSEGGIFNITS
PMCLVSKQNRFRAAEQQISFVCQRVDMDIIVYCNGQKKTILTKTLVIGQCIYTITSLFSLLPGVAHSIAIELCVPGFHGWATAALLITFCFGWVLIPACT
LAILLVLKFFANILHTSNQENRFKAILRKIKEEFEKRKGSMVCEICKYECETLKELKAHNLSCVQGECPYCFTHCEPTETAIQAHYKVCQATHRFREDLK
KTVTPQNIGPGCYRTLNLFRYKSRCYILTMWTLLLIIESILWAASAAEIPLVPLWTDNAHGVGSVPMHTDLELDFSLPSSSKYTYKRHLTNPVNDQQSVS
LHIEIESQGIGADVHHLGHWYDARLNLKTSFHCYGACTKYQYPWHTAKCHFEKDYEYENSWACNPPDCPGVGTGCTACGLYLDQLKPVGTAFKIISVRYS
RKVCVQFGEEHLCKTIDMNDCFVTRHAKICIIGTVSKFSQGDTLLFLGPMEGGGIIFKHWCTSTCHFGDPRDVMGPKDKPFICPEFPGQFRKKCNFATTP
VCEYDGNIISGYKKVLATIDSFQSFNTSNIHFTDERIEWRDPDGMLRDHINIVISKDIDFENLAENPCKVGLQAANIEGAWGSGVGFTLTCQVSLTECPT
FLTSIKACDMAICYGAESVTLSRGQNTVKITGKGGHSGSSFKCCHGKECSSTGLQASAPHLDKVNGISELENEKVYDDGAPECGVTCWFKKSGEWVMGII
NGNWVVLIVLCVLLLFSLILLSILCPVRKHKKS
1133
Not Available
Not Available
01-12-1992
Evidence at transcript level
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Glycoprotein Gn and glycoprotein Gc interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Gn contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).
Not Available
GO:0007165 ; GO:0016021 ; GO:0019031 ; GO:0019062 ; GO:0039503 ;
GO:0039547 ; GO:0039654 ; GO:0044167 ; GO:0044178 ; GO:0055036 ;
GO:0075509
GO:0039547 ; GO:0039654 ; GO:0044167 ; GO:0044178 ; GO:0055036 ;
GO:0075509
♦ Glycoprotein N: Virion membrane . Host Golgi apparatus membrane
♦ Single-pass type I membrane protein . Host endoplasmic reticulum membrane
♦ Single-pass type I membrane protein . Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein N to the Golgi complex, where virion budding occurs. .
♦ Glycoprotein C: Virion membrane . Host Golgi apparatus membrane
♦ Single-pass type I membrane protein .
♦ Single-pass type I membrane protein . Host endoplasmic reticulum membrane
♦ Single-pass type I membrane protein . Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein N to the Golgi complex, where virion budding occurs. .
♦ Glycoprotein C: Virion membrane . Host Golgi apparatus membrane
♦ Single-pass type I membrane protein .
DOMAIN 609 632 ITAM.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available