Reviewed
Homo Sapiens (Human) [TaxID: 9606]
E6
Protein E6
Human Papillomavirus Type ME180
Viruses> DsDNA Viruses> No RNA Stage> Papillomaviridae> Unclassified Papillomaviridae> Human Papillomavirus Types> Human Papillomavirus Type ME180
Not Available
Various pathway(s) in which protein is involved
Not Available
Not Available
MALFHNPEERPYKLPDLCRTLDTTLHDVTIDCVYCRRQLQRTEVYEFAFGDLNVVYRDGVPLAACQSCIKFYAKIRELRYYSESVYATTLETITNTKLYD
LSIRCMCCLKPLSPAEKLRHLNSKRRFHKIAGNFTGQCRHCWTSKREDRRRTRQETQV
LSIRCMCCLKPLSPAEKLRHLNSKRRFHKIAGNFTGQCRHCWTSKREDRRRTRQETQV
158
Not Available
Not Available
01-08-1992
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.
Not Available
GO:0003677 ; GO:0006351 ; GO:0006355 ; GO:0030430 ; GO:0039503 ;
GO:0039526 ; GO:0042025 ; GO:0046872
GO:0039526 ; GO:0042025 ; GO:0046872
Host cytoplasm . Host nucleus .
Not Available
MOTIF 156 158 PDZ-binding domain.
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available