Reviewed
Aedes [TaxID: 7158]; Bos Taurus (Bovine) [TaxID: 9913]; Bos Taurus X Bison Bison (beefalo) [TaxID: 297284]; Camelus Bactrianus (Bactrian Camel) [TaxID: 9837]; Capra Hircus (Goat) [TaxID: 9925]; Homo Sapiens (Human) [TaxID: 9606]; Ovis Aries (Sheep) [TaxID: 9940]; Phlebotomus Papatasi (Sandfly) [TaxID: 29031]
L
RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)
Rift Valley Fever Virus (strain ZH-548 M12) (RVFV)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Bunyavirales> Phenuiviridae> Phlebovirus> Rift Valley Fever Phlebovirus> Rift Valley Fever Virus (strain ZH-548 M12) (RVFV)
Various pathway(s) in which protein is involved
Not Available
Not Available
MDSILSKQLVDKTGFVRVPIKHFDCTMLTLALPTFDVSKMVDRITIDFNLDDIQGASEIGSTLLPSMSIDVEDMANFVHDFTFGHLADKTDRLLMREFPM
MNDGFDHLSPDMIIKTTSGVYNIVEFTNFRGDERGAFQAAMIKLAKYEVPCENRSQGRTVVLYVVSAYRAWCMVYLELERTLKQREMVYRYRLALSVMDE
LRTLFPELSSTDEELGKTERELPAMVSSIQINWSVTESVFPPFSREMFDRFRSSPPDSEYITRIVSRCLINSQEKLINSSFFAEGNDKALRFSKNAEECS
LAVERALNQYRAEDNLRDLNDHKSTIQLPPWLSYHDVDGKDLCPLQGLDVRGDHPMCNLWREVVTSANLEEIERMHDDAAAELEFAFGSKGQARERNRYH
RVHLNMGSDVLVYIAALGVNGKKHKADTLVQQMRDRSKQPFSPDHDVITYLNFSLHALVTCGQQMRTCTALSLVIRDSVGSPEDSSAILVRKGFHEIITE
HYKFMGSRIGHGCQMVSLIGAELSASVKQHVKPNYFVIKRLLGSGIFLLIKPTSSKSHIFVSFALSALAGPLISPLPGFSSPTKMLGILLVTDFVSYKLS
KLTNLCKCVSLMESSFSFWAEAFGIQAGTLVGDFVPRSSDSAAMDASYMGKLSLLTLLEDKAATEELQTIARYIIMEGFVSPPEIPKPHKMTSKFPKVLR
SELQVYLLNCLCRTIQRIAGEPFILKKKDGSISWGGMFNPFSGRPLLDMQPLISCCYNGYFKNKEEETEPSSLSGMYKKIIELEHLRPQSDAFLGYKDPE
LPRMHEFSVSYLKEACNHAKLVLRSLYGQNFMEQIDNQIIRELSGLTLERLATLKATSNFNENWYVYKDVADKNYTRDKLLVKMSKYASEGKSLAIQKFE
DCMRQIESQGCMHICLFKKQQHGGLREIYVMGAEERIVQSVVETIARSIGKFFASDTLCNPPNKVKIPETHGIRARKQCKGPVWTCATSDDARKWNQGHF
VTKFALMLCEFTSPKWWPLIIRGCSMFTKKRMMMNLNYLKILDGHRELDIRDDFVMDLFKAYHGEAEVPWAFKGKTYLETTTGMMQGILHYTSSLLHTIH
QEYIRSLSFKIFNLKVAPEMSKSLVCDMMQGSDDSSMLISFPADDEKVLTRCKVAAAICFRMKKELGVYLAIYPSEKSTANTDFVMEYNSEFYFHTQHVR
PTIRWIAACCSLPEVETLVARQEEASNLMTSVTEGGGSFSLAAIIQQAQCTLHYMLMGMGVSELFLEYKKAVLKWNDPGLGFFLLDNPYACGLGGFRFNL
FKAITRTDLQKLYAFFMKKVKGSAARDWADEDVTIPETCSVSPGGALILSSSLKWGSRKKFQKLRDRLNIPENWIELINENPEVLYRAPRTGPEILLRIA
EKVHSPGVVSSLSSGNAVCKVMASAVYFLSATIFEDTGRPEFNFLEDSKYSLLQKMAAYSGFHGFNDMEPEDILFLFPNIEELESLDSIVYNKGEIDIIP
RVNIRDATQTRVTIFNEQKNLRTSPEKLVSDKWFGTQKSRIGKTTFLAEWEKLKKIVKWLEDAPEATLAHTPLNNHIQVRNFFARMESKPRTVRITGAPV
KKRSGVSKIAMVIRDHFSRMGHLRGVEDLAGFTRSVSAEILKHFLFCILQGPYSESYKLQLIYRVLSSVSNVEIKESDGKTKTNLIGILQRFLDGDHVVP
IIEEMGAGTVGGFIKRQQSKVVQNKVVYYGVGIWRGFMDGYQVHLEIENDIGQPPRLRNVTTNCQSSPWDLSIPIRQWAEDMGVTNNQDYSSKSSRGARY
WMHSFRMQGPSKPFGCPVYIIKGDMSDVIRLRKEEVEMKVRGSTLNLYTKHHSHQDLHILSYTASDNDLSPGIFKSISDEGVAQALQLFEREPSNCWVRC
ESVAPKFISAILEICEGKRQIKGINRTRLSEIVRICSESSLRSKVGSMFSFVANVEEAHDVDYDALMDLMIEDAKNNAFSHVVDCIELDVSGPYEMESFH
GRSTLTCTPSTILIRTYTFYLTLHQTMISVQAFQVILDEGVLLIALVNNYLRGSKANCWVRCESVAPKFISAILEICEGKRQIKGINRTRLSEIVEFVLN
LPKIKSRIYVLICRQCHGANFPPISVRRLMLEDIASVARRLIIVASFGS
MNDGFDHLSPDMIIKTTSGVYNIVEFTNFRGDERGAFQAAMIKLAKYEVPCENRSQGRTVVLYVVSAYRAWCMVYLELERTLKQREMVYRYRLALSVMDE
LRTLFPELSSTDEELGKTERELPAMVSSIQINWSVTESVFPPFSREMFDRFRSSPPDSEYITRIVSRCLINSQEKLINSSFFAEGNDKALRFSKNAEECS
LAVERALNQYRAEDNLRDLNDHKSTIQLPPWLSYHDVDGKDLCPLQGLDVRGDHPMCNLWREVVTSANLEEIERMHDDAAAELEFAFGSKGQARERNRYH
RVHLNMGSDVLVYIAALGVNGKKHKADTLVQQMRDRSKQPFSPDHDVITYLNFSLHALVTCGQQMRTCTALSLVIRDSVGSPEDSSAILVRKGFHEIITE
HYKFMGSRIGHGCQMVSLIGAELSASVKQHVKPNYFVIKRLLGSGIFLLIKPTSSKSHIFVSFALSALAGPLISPLPGFSSPTKMLGILLVTDFVSYKLS
KLTNLCKCVSLMESSFSFWAEAFGIQAGTLVGDFVPRSSDSAAMDASYMGKLSLLTLLEDKAATEELQTIARYIIMEGFVSPPEIPKPHKMTSKFPKVLR
SELQVYLLNCLCRTIQRIAGEPFILKKKDGSISWGGMFNPFSGRPLLDMQPLISCCYNGYFKNKEEETEPSSLSGMYKKIIELEHLRPQSDAFLGYKDPE
LPRMHEFSVSYLKEACNHAKLVLRSLYGQNFMEQIDNQIIRELSGLTLERLATLKATSNFNENWYVYKDVADKNYTRDKLLVKMSKYASEGKSLAIQKFE
DCMRQIESQGCMHICLFKKQQHGGLREIYVMGAEERIVQSVVETIARSIGKFFASDTLCNPPNKVKIPETHGIRARKQCKGPVWTCATSDDARKWNQGHF
VTKFALMLCEFTSPKWWPLIIRGCSMFTKKRMMMNLNYLKILDGHRELDIRDDFVMDLFKAYHGEAEVPWAFKGKTYLETTTGMMQGILHYTSSLLHTIH
QEYIRSLSFKIFNLKVAPEMSKSLVCDMMQGSDDSSMLISFPADDEKVLTRCKVAAAICFRMKKELGVYLAIYPSEKSTANTDFVMEYNSEFYFHTQHVR
PTIRWIAACCSLPEVETLVARQEEASNLMTSVTEGGGSFSLAAIIQQAQCTLHYMLMGMGVSELFLEYKKAVLKWNDPGLGFFLLDNPYACGLGGFRFNL
FKAITRTDLQKLYAFFMKKVKGSAARDWADEDVTIPETCSVSPGGALILSSSLKWGSRKKFQKLRDRLNIPENWIELINENPEVLYRAPRTGPEILLRIA
EKVHSPGVVSSLSSGNAVCKVMASAVYFLSATIFEDTGRPEFNFLEDSKYSLLQKMAAYSGFHGFNDMEPEDILFLFPNIEELESLDSIVYNKGEIDIIP
RVNIRDATQTRVTIFNEQKNLRTSPEKLVSDKWFGTQKSRIGKTTFLAEWEKLKKIVKWLEDAPEATLAHTPLNNHIQVRNFFARMESKPRTVRITGAPV
KKRSGVSKIAMVIRDHFSRMGHLRGVEDLAGFTRSVSAEILKHFLFCILQGPYSESYKLQLIYRVLSSVSNVEIKESDGKTKTNLIGILQRFLDGDHVVP
IIEEMGAGTVGGFIKRQQSKVVQNKVVYYGVGIWRGFMDGYQVHLEIENDIGQPPRLRNVTTNCQSSPWDLSIPIRQWAEDMGVTNNQDYSSKSSRGARY
WMHSFRMQGPSKPFGCPVYIIKGDMSDVIRLRKEEVEMKVRGSTLNLYTKHHSHQDLHILSYTASDNDLSPGIFKSISDEGVAQALQLFEREPSNCWVRC
ESVAPKFISAILEICEGKRQIKGINRTRLSEIVRICSESSLRSKVGSMFSFVANVEEAHDVDYDALMDLMIEDAKNNAFSHVVDCIELDVSGPYEMESFH
GRSTLTCTPSTILIRTYTFYLTLHQTMISVQAFQVILDEGVLLIALVNNYLRGSKANCWVRCESVAPKFISAILEICEGKRQIKGINRTRLSEIVEFVLN
LPKIKSRIYVLICRQCHGANFPPISVRRLMLEDIASVARRLIIVASFGS
2149
Not Available
Not Available
01-08-1992
Evidence at protein level
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes several subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. During replication, makes copies of the genomic or antigenomic RNAs. The new genomes/antigenomes are encapsidated during synthesis by the nucleoprotein, and non capped/polyadenylated.
2.7.7.48
Not Available
DOMAIN 975 1166 RdRp catalytic.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available