Results | viHumans

UniProt ID

P26578

Status

Reviewed

Host

Calomys Callosus (Large Vesper Mouse) [TaxID: 56210]; Chlorocebus Aethiops (Green Monkey) (Cercopithecus Aethiops) [TaxID: 9534]; Homo Sapiens (Human) [TaxID: 9606]

Gene Name

N

Protein Name

Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Organism Name

Machupo Virus (MACV)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Arenaviridae> Mammarenavirus> Machupo Virus (MACV)

RefSeq

NC_005079.1 ; AY129248.1 ; NC_005078.1 ; AY129248.1

PubMed ID

1318712

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MAHSKEIPSFRWTQSLRRGLSQVHPTVKTDVLKDAKLIADSIDFNQVSQVQRALRKNKRGEEDLNKLRDLNKEVDRLMSMKSIQKNTIFKIGDLGRDELM
ELASDLEKLKNKIKRTESGPQGLYMGNLSQLQLTKRSEILKTLGFQQQRGAGNGVVRIWDVSDPSKLNNQFGSMPALTIACMTVQGGETMNSVVQALTSL
GLLYTVKYPNLNDLDKLTLEHECLQIVTKDESSINISGYNFSLSAAVKAGASILDGGNMLETIRVTPDNFSSLIKSTLQVKRKEGMFIDEKPGNRNPYEN
LLYKLCLSGDGWPYIGSRSQILGRSWDNTSVDLTKKPQVGPRQPEKNGQNLRLANLTEMQEAVIKEAVKKLDPTNTLWLDIEGPPTDPVELALYQPANKH
YIHCFRKPHDEKGFKNGSRHSHGILMQDIEDAMPGVLSYVIGLLPQDMVITTQGSDDIRKLLDIHGRKDLKLVDVKLTSDQARLYDQQIWEKFGHLCKHH
NGVVVNKKKREKDSPFKLSSGEPHCALLDCIMYQSVMDGKMVDEEPVALLPLSLLFLPKAAFAL
						

Length

564

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-08-1992

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and therby participates in the suppression of interferon induction.

EC

3.1.13.-

Experimentally known GO terms

GO:0003723 ; GO:0016787 ; GO:0019013 ; GO:0019029 ; GO:0030430 ;
GO:0039689 ; GO:0039696 ; GO:0039724 ; GO:0046872

Subcellular Location

Virion . Host cytoplasm .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available