Results | viHumans

UniProt ID

P26036

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

P/V

Protein Name

Non-structural protein V

Organism Name

Measles Virus (strain IP-3-Ca) (MeV) (Subacute Sclerose Panencephalitis Virus)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Paramyxoviridae> Morbillivirus> Measles Morbillivirus> Measles Virus (strain IP-3-Ca) (MeV) (Subacute Sclerose Panencephalitis Virus)

RefSeq

NC_001498.1 ; AB016162.1

PubMed ID

1585658

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MAEEQARHVKNGLECIRALKAEPIGSLAIGEAMAAWSEISDNPGQEQATCKEEEAGASGLSKPCLSAIGSTEGGAPRIRGQGSGESDDDTETLGFPSRNL
QASSTGLQCYYVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDNESENSDVDIGEPDTEGYAITDRGPAPISMGFRASDVETAEGGEIHELLRLQSRG
NNFPKLGKTLNVPPPPDPGRASTSETPIKKGHRREISLIWDGDRVFIDRWCNPMCSKVTLGTIRARCTCGECPRVCEQCRTDTGVDTRIWYHNLPEIPE
						

Length

299

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-05-1992

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Moderately affects the type II interferon signaling (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0030430 ; GO:0039502 ; GO:0039554 ; GO:0039557 ; GO:0039564 ;
GO:0046872

Subcellular Location

Host cytoplasm .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available