Reviewed
Homo Sapiens (Human) [TaxID: 9606]
HN
Hemagglutinin-neuraminidase (EC 3.2.1.18)
Human Parainfluenza 4a Virus (strain Toshiba) (HPIV-4a)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Paramyxoviridae> Rubulavirus> Human Rubulavirus 4> Human Parainfluenza Virus 4a> Human Parainfluenza 4a Virus (strain Toshiba) (HPIV-4a)
Various pathway(s) in which protein is involved
Not Available
Not Available
MQDSHGNTQILNQANSMVKRTWRLLFRIATLILLVSIFVLSLIIVLQSTPGNLQNDINIIRKELNELMENFETTSKSLLSVSNQITYDVSVLTPIRQEAI
ETNIISKIKDHCKDRVIKEGSTCTLNRSPLHDVSFLNGFNKFYFTYKDNMQIKFKSLLDYPNFIPTATTPHGCIRIPSFSLGQTHWCYTHNINLLGCADP
ASSNQYVSLGTLQVLKMGDPYFKVEHSHYLNDGRNRKSCSVVAVPDGCLRNCVTMTKNETENFKDLNWQHNYLHTYHIMVPLKTRIINPPGSSRDWVHIA
PGVGSGLLYAKLLIFPLYGGLTEKSVIHNNQSGKYFFPNSTKLQCRNSTMEKIKGAKDSYTITYFSGRLIQSAFLVCDLRQFLSEDCEILIPSNDYMMVG
AEGRLYNIENNIFYYQRGSSWWPYPSLYRIRLNLSKKYPRITEIKFTKIEIAPRPGNKDCPGNKACPKECITGVYQDILPLSYPNTAFPHLKQAYYTGFY
LNNSLERRNPTFYTADNLDYHQQERLGKFNLTAGYSTTTCFKQTTTARLYCLYIIEVGDSVIGDFQITLFLAA
ETNIISKIKDHCKDRVIKEGSTCTLNRSPLHDVSFLNGFNKFYFTYKDNMQIKFKSLLDYPNFIPTATTPHGCIRIPSFSLGQTHWCYTHNINLLGCADP
ASSNQYVSLGTLQVLKMGDPYFKVEHSHYLNDGRNRKSCSVVAVPDGCLRNCVTMTKNETENFKDLNWQHNYLHTYHIMVPLKTRIINPPGSSRDWVHIA
PGVGSGLLYAKLLIFPLYGGLTEKSVIHNNQSGKYFFPNSTKLQCRNSTMEKIKGAKDSYTITYFSGRLIQSAFLVCDLRQFLSEDCEILIPSNDYMMVG
AEGRLYNIENNIFYYQRGSSWWPYPSLYRIRLNLSKKYPRITEIKFTKIEIAPRPGNKDCPGNKACPKECITGVYQDILPLSYPNTAFPHLKQAYYTGFY
LNNSLERRNPTFYTADNLDYHQQERLGKFNLTAGYSTTTCFKQTTTARLYCLYIIEVGDSVIGDFQITLFLAA
573
Not Available
Not Available
01-05-1991
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).
♦ Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
♦ Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
3.2.1.18
GO:0016021 ; GO:0019031 ; GO:0019062 ; GO:0020002 ; GO:0046718 ;
GO:0046789 ; GO:0052794 ; GO:0052795 ; GO:0052796 ; GO:0055036
GO:0046789 ; GO:0052794 ; GO:0052795 ; GO:0052796 ; GO:0055036
♦ Virion membrane
♦ Single-pass type II membrane protein . Host cell membrane
♦ Single-pass type II membrane protein .
♦ Single-pass type II membrane protein . Host cell membrane
♦ Single-pass type II membrane protein .
Not Available
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Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available