Reviewed
Homo Sapiens (Human) [TaxID: 9606]; Myodes Glareolus (Bank Vole) (Clethrionomys Glareolus) [TaxID: 447135]
GP
♦Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1)
♦ Glycoprotein C (Gc) (Glycoprotein G2)]
♦ Glycoprotein C (Gc) (Glycoprotein G2)]
Puumala Virus (strain Bank Vole/Russia/CG1820/1984)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Bunyavirales> Hantaviridae> Orthohantavirus> Puumala Orthohantavirus> Puumala Virus (strain Bank Vole/Russia/CG1820/1984)
Various pathway(s) in which protein is involved
Not Available
Not Available
MGELSPVCLYLLLQGLLLCNTGAARNLNELKMECPHTIRLGQGLVVGSVELPSLPIQQVETLKLESSCNFDLHTSTAGQQSFTKWTWEIKGDLAENTQAS
STSFQTKSSEVNLRGLCLIPTLVVETAARMRKTIACYDLSCNQTVCQPTVYLMGPIQTCITTKSCLLSLGDQRIQVNYEKTYCVSGDLVEGICFNPIHTM
ALSQPSHTYDIMTMMVRCFLVIKKVTSGDSMKIEKNFETLVQKNGCTANNFQGYYICLIGSSSEPLYVPALDDYRSAEVLSRMAFAPHGEDHDIEKNAVS
AMRIAGKVTGKVPSTESSDTVQGIAFSGSPLYTSTGVLTSKDDPVYIWAPGIIMEGNHSICEKKTLPLTWTGFISLPGEIEKTTQCTVFCTLAGPGADCE
AYSETGIFNISSPTCLINRVQRFRGSEQQIKFVCQRVDMDITVYCNGMKKVILTKTLVIGQCIYTFTSIFSLIPGVAHSLAVELCVPGLHGWATMLLLLT
FCFGWVLIPTITMILLKILIAFAYLCSKYNTDSKFRILIEKVKREYQKTMGSMVCEVCQYECETAKELESHRKSCSIGSCPYCLNPSEATTSALQAHFKV
CKLRSRFQENLRKSLTVYEPMQGCYRTLSLFRYRSRFFVGLVWCVLLVHHLIVWAASAETQNLNAGWTDTAHGSRIIPMKTDLELDFSLQSSASYTYRRQ
LQNPANEQEKIPFHLQLSKQVIHAEIQHLGHWMDATFNLKTAFHCYGSCEKYAYPWQTAGCFIEKDYEYETGWGCNPPDCPGVGTGCTACGVYLDKLKSV
GKVFKIVSLRYTRKVCIQLGTEQTCKTVDSNDCLITTSVKVCLIGTISKFQPSDTLLFLGPLQQGGLIFKQWCTTTCQFGDPGDIMSTPTGMKCPELNGS
FRKKCAFATTPVCQFDGNTISGYKRMIATKDSFQSFNVTEPHISTSALEWIDPDSSLRDHINVIVSRDLSFQDLSETPCQIDLATASIDGAWGSGVGFNL
VCTVSLTECSAFLTSIKACDAAMCYGSTTANLVRGQNTIHIVGKGGHSGSKFMCCHDTKCSSTGLVAAAPHLDRVTPYNQADSDKIFDDGAPECGMSCWF
KKSGEWILGVLNGNWMVVAVLVVLLILSILLFTLCCPRRPSYRKEHKP
STSFQTKSSEVNLRGLCLIPTLVVETAARMRKTIACYDLSCNQTVCQPTVYLMGPIQTCITTKSCLLSLGDQRIQVNYEKTYCVSGDLVEGICFNPIHTM
ALSQPSHTYDIMTMMVRCFLVIKKVTSGDSMKIEKNFETLVQKNGCTANNFQGYYICLIGSSSEPLYVPALDDYRSAEVLSRMAFAPHGEDHDIEKNAVS
AMRIAGKVTGKVPSTESSDTVQGIAFSGSPLYTSTGVLTSKDDPVYIWAPGIIMEGNHSICEKKTLPLTWTGFISLPGEIEKTTQCTVFCTLAGPGADCE
AYSETGIFNISSPTCLINRVQRFRGSEQQIKFVCQRVDMDITVYCNGMKKVILTKTLVIGQCIYTFTSIFSLIPGVAHSLAVELCVPGLHGWATMLLLLT
FCFGWVLIPTITMILLKILIAFAYLCSKYNTDSKFRILIEKVKREYQKTMGSMVCEVCQYECETAKELESHRKSCSIGSCPYCLNPSEATTSALQAHFKV
CKLRSRFQENLRKSLTVYEPMQGCYRTLSLFRYRSRFFVGLVWCVLLVHHLIVWAASAETQNLNAGWTDTAHGSRIIPMKTDLELDFSLQSSASYTYRRQ
LQNPANEQEKIPFHLQLSKQVIHAEIQHLGHWMDATFNLKTAFHCYGSCEKYAYPWQTAGCFIEKDYEYETGWGCNPPDCPGVGTGCTACGVYLDKLKSV
GKVFKIVSLRYTRKVCIQLGTEQTCKTVDSNDCLITTSVKVCLIGTISKFQPSDTLLFLGPLQQGGLIFKQWCTTTCQFGDPGDIMSTPTGMKCPELNGS
FRKKCAFATTPVCQFDGNTISGYKRMIATKDSFQSFNVTEPHISTSALEWIDPDSSLRDHINVIVSRDLSFQDLSETPCQIDLATASIDGAWGSGVGFNL
VCTVSLTECSAFLTSIKACDAAMCYGSTTANLVRGQNTIHIVGKGGHSGSKFMCCHDTKCSSTGLVAAAPHLDRVTPYNQADSDKIFDDGAPECGMSCWF
KKSGEWILGVLNGNWMVVAVLVVLLILSILLFTLCCPRRPSYRKEHKP
1148
Not Available
Not Available
01-08-1992
Inferred from homology
Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
---|---|---|---|---|---|
Alanine (A) | Leucine (L) | ||||
Arginine (R) | Lysine (K) | ||||
Asparagine (N) | Methionine (M) | ||||
Aspartic Acid (D) | Phenylalanine (F) | ||||
Cysteine (C) | Proline (P) | ||||
Glutamine (Q) | Serine (S) | ||||
Glutamic Acid (E) | Threonine (T) | ||||
Glycine (G) | Tryptophan (W) | ||||
Histidine (H) | Tyrosine (Y) | ||||
Isoleucine (I) | Valine (V) |
% Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
---|---|---|
Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Glycoprotein N contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).
Not Available
GO:0007165 ; GO:0016021 ; GO:0019062 ; GO:0039503 ; GO:0039547 ;
GO:0039654 ; GO:0044167 ; GO:0044178 ; GO:0055036
GO:0039654 ; GO:0044167 ; GO:0044178 ; GO:0055036
♦ Glycoprotein N: Virion membrane . Host Golgi apparatus membrane
♦ Single-pass type I membrane protein . Host endoplasmic reticulum membrane
♦ Single-pass type I membrane protein . Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein N to the Golgi complex, where virion budding occurs. .
♦ Glycoprotein C: Virion membrane . Host Golgi apparatus membrane
♦ Single-pass type I membrane protein .
♦ Single-pass type I membrane protein . Host endoplasmic reticulum membrane
♦ Single-pass type I membrane protein . Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein N to the Golgi complex, where virion budding occurs. .
♦ Glycoprotein C: Virion membrane . Host Golgi apparatus membrane
♦ Single-pass type I membrane protein .
DOMAIN 621 644 ITAM.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available