Results | viHumans

UniProt ID

P21090

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

C23L; B29R

Protein Name

Inactive chemokine-binding protein (vCKBP)

Organism Name

Vaccinia Virus (strain Copenhagen) (VACV)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Vaccinia Virus> Vaccinia Virus (strain Copenhagen) (VACV)

RefSeq

NC_006998.1 ; AY243312.1

PubMed ID

2219722

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MHVPASLQQSSSSSSSCTEEENKHHMGIDVIIKVTKQDQTPTNDKICQSVTEITESESDPDPEVESEDDSTSVEDVDPPTTYYSIIGGGLRMNFGFTKCP
QIKSISESADGNTVNARLSSVSPGQGKDSPAITREEALAMIKDCEVSIDIRCSEEEKDSDIKTHPVLGSNISHKKVSYEDIIGSTIVDTKCVKNLEFSVR
IGDMCKESSELEVKDGFKYVDGSASEGATDDTSLIDSTKLKACV
						

Length

244

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-02-1991

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

The protein is truncated in this vaccinal strain and presumably inactive, because the lack of signal peptide prevents the protein of being secreted. In the other strains inhibits host immune defense by binding to host chemokines. Binds host CC chemokines (beta chemokines) such as RANTES with high affinity, but not CXC or C chemokines (alpha and gamma chemokines) (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0030430

Subcellular Location

Host cytoplasm . Note=the wild-type protein is secreted, but this strain encodes a truncated form which lacks the signal peptide. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available