Results | viHumans

UniProt ID

P17151

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

UL112/UL113

Protein Name

♦Early phosphoprotein p84 [Cleaved into: p20
♦ p26
♦ p28]

Organism Name

Human Cytomegalovirus (strain AD169) (HHV-5) (Human Herpesvirus 5)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Cytomegalovirus> Human Cytomegalovirus (HHV-5) (Human Herpesvirus 5)> Human Cytomegalovirus (strain AD169) (HHV-5) (Human Herpesvirus 5)

RefSeq

Not Available

PubMed ID

2161319 ; 12533697 ; 2824853 ; 2542619 ; 15452216 ; 16501081 ; 19656965 ; 25564485

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MDLPTTVVRKYWTFANPNRILHQSVNQTFDVRQFVFDTARLVNCVDGDGKVLHLNKGWLCATIMQHGEASAGAKTQQGFMSIDITGDGELQEHLFVRGGI
VFNKSVSSVVGSSGPNESALLTMISENGNLQVTYVRHYLKNHGESSSGGGGCGAASTASAVCVSSLGGSGGTRDGPSAEEQQRRRQEQRHEERRKKSSSS
AGGGGGGGAGGGGGGGGSGGQHSSDSANGLLRDPRLMNRQKERRPPPSSENDGSPPLREAKRQKTTAQHEGHGGGGKNETEQQSGGAGGGGGGGSGRMSL
PLDTSEAVAFLNYSSSSSAVSSSSNNHHHHHHHHNAVTDVAAGTDGALLLPIERGAVVSSPSSTSPSSLLSLPRPSSAHSAGETVQESEAAATAAAAGLM
MMRRMRRAPAEAAEAPPQSEEENDSTTPVSNCRVPPNSQESAAPQPPRSPRFDDIIQSLTKMLNDCKEKRLCDLPLVSSRLLPETSGGTVVVNHSSVART
AAAVSAAGVGPPAAACPPLVTTGVVPSGSVAGVAPVAAAIETPAAPPRPVCEIKPYVVNPVVATAAAASNSSSSSSAPLPPPPPPSGGRRGRARNNTRGG
GGGGGGRNSRRQAASSSSSSSRRSRRRNNRHEDEEDNDPLLRLSQVAGNGRRRGPSFLEDGLEIIDPSEEAAIAAASIAAFFDD
						

Length

684

Alternate Sequence

VAR_SEQ 254 268 SPPLREAKRQKTTAQ -> ESRPSSRHGAFRVDS (in isoform p34) Ref2 ; VAR_SEQ 269 684 Missing (in isoform p34) Ref2 ; VAR_SEQ 346 423 GALLLPIERGAVVSSPSSTSPSSLLSLPRPSSAHSAGETVQESEAAATAAAAGLMMMRRMRRAPAEAAEAPPQSEEEN -> DSCQRRRAGLSSSTTAASRGPPQLSPQPALAPQQPHVRHSSPPVLYPQVPSPVSRPLPPQSKHQLLLPGPCVKSSPTW (in isoform p50) Ref2 ; VAR_SEQ 347 358 ALLLPIERGAVV -> IRGASASSQSAF (in isoform p43) Ref2 ; VAR_SEQ 359 684 Missing (in isoform p43) Ref2 ; VAR_SEQ 424 684 Missing (in isoform p50) Ref2

Non-standard residue

Not Available

Date of last Sequence modification

30-05-2000

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Promotes efficient viral DNA replication. Recruits the DNA polymerase processivity factor to pre-replication foci.

EC

Not Available

Experimentally known GO terms

GO:0019012 ; GO:0039686 ; GO:0042025

Subcellular Location

♦ Host nucleus , . Virion . Note=Found in subnuclear structures known as promyelocytic leukemia oncogenic domains (PODs) or nuclear domain 10 (ND10) during the early stages of viral infection ().
♦ p20: Virion .
♦ p26: Virion .
♦ p28: Virion .

Domain(s)

Not Available

Motif(s)

MOTIF 261 264 Nuclear localization signal.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available