Results | viHumans

UniProt ID

P16849

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

UL33

Protein Name

G-protein coupled receptor homolog UL33 (vGPCR UL33)

Organism Name

Human Cytomegalovirus (strain AD169) (HHV-5) (Human Herpesvirus 5)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Cytomegalovirus> Human Cytomegalovirus (HHV-5) (Human Herpesvirus 5)> Human Cytomegalovirus (strain AD169) (HHV-5) (Human Herpesvirus 5)

RefSeq

Not Available

PubMed ID

2161319 ; 2158627 ; 12533697 ; 11886592 ; 14522997 ; 15452216 ; 15172446 ; 21684267

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MDTIIHNSTRNNTPPHINDTCNMTGPLFAIRTTEAVLNTFIIFVGGPLNAIVLITQLLTNRVLGYSTPTIYMTNLYSTNFLTLTVLPFIVLSNQWLLPAG
VASCKFLSVIYYSSCTVGFATVALIAADRYRVLHKRTYARQSYRSTYMILLLTWLAGLIFSVPAAVYTTVVMHHDANDTNNTNGHATCVLYFVAEEVHTV
LLSWKVLLTMVWGAAPVIMMTWFYAFFYSTVQRTSQKQRSRTLTFVSVLLISFVALQTPYVSLMIFNSYATTAWPMQCEHLTLRRTIGTLARVVPHLHCL
INPILYALLGHDFLQRMRQCFRGQLLDRRAFLRSQQNQRATAETNLAAGNNSQSVATSLDTNSKNYNQHAKRSVSFNFPSGTWKGGQKTASNDTSTKIPH
RLSQSHHNLSGV
						

Length

412

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

15-02-2005

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

G-protein-coupled receptor (vGPCR) that constitutively activates multiple signaling pathways in a ligand independent manner. For example, promotes phospholipase C and cAMP-responsive element (CRE) pathway activation. Therefore, greatly contributes to viral pathogenesis. Inhibits US28-mediated NF-kappa-B activation.

EC

Not Available

Experimentally known GO terms

GO:0004930 ; GO:0016021 ; GO:0019012 ; GO:0020002 ; GO:0030683 ;
GO:0039553

Subcellular Location

♦ Virion . Host cell membrane
♦ Multi-pass membrane protein .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available