Results | viHumans

UniProt ID

P11823

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

L4[Gene ID: 2715920 ]

Protein Name

Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)

Organism Name

Human Adenovirus F Serotype 40 (HAdV-40) (Human Adenovirus 40)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus F> Human Adenovirus F Serotype 40 (HAdV-40) (Human Adenovirus 40)

RefSeq

NC_001454.1 ; L19443.1

PubMed ID

8263936 ; 3279700

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:2715920

Reactome

Not Available

Sequence

							MEEDLKLQPDSETLTTPNSEVGAVELVKHEEENEQVEQDPGYVTPPEDGKEPVAALSEPNYLGGEDDVLLKHIARQSTIVREALKECTQTPLTVEELSRA
YEANLFSPRVPPKKQPNGTCETNPRLNFYPVFAVPEALATYHIFFKNQRIPLSCRANRTRGDGLLHLKAGAHIPEIVSLEEVPKIFEGLGKDEKRAANAL
QKNETENQNVLVELEGDNARLAVLKRTIEVSHFAYPALNLPPKVMRSVMDQVLIKRAEPIDPQQPDLNSEDGQPVVSDDELARWLGTQDPSELQERRKMM
MAAVLVTVELECLQRFFANPQTLRKVEESLHYAFRHGYVRQACKISNVELSNLISYMGILHENRLGQNVLHCTLQGEARRDYVRDCIYLFLILTWQTAMG
VWQQCLEEQNLQELNKLLVRARRELWTSFDERTVARQLANLIFPERLMQTLQNGLPDFVSQSILQNFRSFVLERSGILPAMSCALPSDFVPLCYRECPPP
LWSHCYLLRLANYLAHHSDLMEDSSGDGLLECHCRCNLCTPHRSLVCNTELLSETQVIGTFEIQGPEQQEGASSLKLTPALWTSAYLRKFIPEDYHAHQI
KFYEDQSRPPKVPLTACVITQSQILAQLQAIQQARQEFLLKKGHGVYLDPQTGEELNTPSLSAAASCRSQKHATQGKQASHRATAIPAETTKAVGRGGDV
GRQPGRGSFRRGGGGADGELGQPRRGGPRGRGGRNHRQRQGTIFQKTRSEPTSENYPAPATATMFTESQP
						

Length

770

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-02-1996

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Protein that inhibits host translation while promoting late viral translation by ribosome shunting. Blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation. Binds to the tripartite leader sequence of viral late mRNAs and recruits host eIF4G, PABPC1/poly-A binding protein and 40S ribosomes subunits on viral mRNAs, allowing ribosome shunting and efficient translation of late viral mRNAs even though conventional translation via ribosome scanning from the cap has been shut off in the host cell. During assembly, acts as a chaperone protein that helps hexon proteins assembly into trimers.

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0030430 ; GO:0039657 ; GO:0039704

Subcellular Location

Host cytoplasm .

Domain(s)

DOMAIN 315 433 RRM.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available