Results | viHumans

UniProt ID

P11136

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

PA

Protein Name

Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

Organism Name

Influenza B Virus (strain B/Singapore/222/1979)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Orthomyxoviridae> Betainfluenzavirus> Influenza B Virus> Influenza B Virus (strain B/Singapore/222/1979)

RefSeq

NC_002205.1 ;  AF102017.1 ;  NC_002206.1 ;  AF102017.1 ;  NC_002207.1 ;  M14880.1 ;  NC_002208.1 ;
K01395.1 ;  NC_002209.1 ;  J02095.1 ;  NC_002210.1 ;  AF101982.1 ;  NC_002211.1 ;  K00423.1 ;
RNA 1:NC_002204.1 ;  M14880.1

PubMed ID

3604058

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MDTFITRNFQTTIIQKAKNTMAEFMEDPELQPAMLFNICVHLEVCYVISDMNFLDEEGKAYTALEGQGKEQNLRPQYEVIEGMPRNIAWMVQRSLAQEHG
IETPKYLADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSNESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDIEKGI
DFKLGQTISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLKWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSK
KPKTLAKECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEETSNELQKTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVA
AWVQTEMNLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYVLFHTSLLNESNASMGKYKVIPITNRVNEKGESFDMLYGLAV
KGQSHLRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTK
ACFKEDRVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAY
WFNEWLGFEKEGSKVLESVDEIMDE
						

Length

725

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1989

Protein Existence

Evidence at transcript level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.

EC

3.1.-.-

Experimentally known GO terms

GO:0003723 ; GO:0004519 ; GO:0030430 ; GO:0039523 ; GO:0039694 ;
GO:0042025 ; GO:0046872 ; GO:0075526

Subcellular Location

Host cytoplasm . Host nucleus . Note=PB1 and PA are transported in the host nucleus as a complex. .

Domain(s)

Not Available

Motif(s)

MOTIF 125 140 Nuclear localization signal 1 (NLS1). ; MOTIF 183 244 Nuclear localization signal 2 (NLS2).

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available