Reviewed
Homo Sapiens (Human) [TaxID: 9606]
Not Available
E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
Human Adenovirus F Serotype 40 (HAdV-40) (Human Adenovirus 40)
Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus F> Human Adenovirus F Serotype 40 (HAdV-40) (Human Adenovirus 40)
Various pathway(s) in which protein is involved
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MERPNSSVAGLYSGLHGNGSVENLATEEEGLRLLAGAASARFGSSAGRGGGGGEPEGRPGPFNGIVTEPDPEEGTSSGQRGGINGQRGTKRKMENEGEDF
LKELTLSLMSRRHHESVWWADLEDEFKNGEMNLLYKYTFEQLKTHWLEAWEDFELALNTFAKVALRPDTIYTIKKTVNIRKCAYVLGNGAVVRFQTCDRV
AFNCAMQSLGPGLIGMSGVTFMNVRFVVEGFNGTVFASTTQLTLHGVFFQNCSGICVDSWGRVSARGCTFVACWKGVVGRNKSQMSVKKCVFERCIMAMV
VEGQARIRHNAGSDNVCFLLLKGTASVKHNMICGGGHSQLLTCADGNCQALRVFHVVSHPRRPWPVFEHNMLMRCTVHLGARRGMFSPYQSNFCHTKVLM
ETDAFSRVWWNGVFDLTMELFKVVRYDESKVRCRPCECGANHIRLYPATLNVTEQLRTDHQMMSCLRTDYESSDED
LKELTLSLMSRRHHESVWWADLEDEFKNGEMNLLYKYTFEQLKTHWLEAWEDFELALNTFAKVALRPDTIYTIKKTVNIRKCAYVLGNGAVVRFQTCDRV
AFNCAMQSLGPGLIGMSGVTFMNVRFVVEGFNGTVFASTTQLTLHGVFFQNCSGICVDSWGRVSARGCTFVACWKGVVGRNKSQMSVKKCVFERCIMAMV
VEGQARIRHNAGSDNVCFLLLKGTASVKHNMICGGGHSQLLTCADGNCQALRVFHVVSHPRRPWPVFEHNMLMRCTVHLGARRGMFSPYQSNFCHTKVLM
ETDAFSRVWWNGVFDLTMELFKVVRYDESKVRCRPCECGANHIRLYPATLNVTEQLRTDHQMMSCLRTDYESSDED
476
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01-07-1989
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Plays a major role to prevent cellular inhibition of viral genome replication. Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6. This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM. Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest. E1B-55K also inactivates TP53 transcription-factor activity by binding its transactivation domain. E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies thereby contributing to maximal inhibition of TP53 function.
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Host nucleus . Host cytoplasm . Note=Colocalizes with host TP53 to host PML nuclear bodies. PML localization of E1B-55K is necessary for E1B-55K-dependent SUMOylation of TP53. .
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Predicted/Modelled
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Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available