Results | viHumans

UniProt ID

P10406

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

Not Available

Protein Name

E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

Organism Name

Human Adenovirus E Serotype 4 (HAdV-4) (Human Adenovirus 4)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus E> Human Adenovirus E Serotype 4 (HAdV-4) (Human Adenovirus 4)

RefSeq

NC_003266.2 ; AY487947.1

PubMed ID

2947381

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MEIWTVLEDFHKTRQLLENASNGVSHLWRFCFGGDLAKLVYRAKQDYREQFEDILRECPSLFDALNLGHQSHFNQRISRALDFTTPGRTTAAVAFFAFIF
DKWSQETHFSRDYQLDFLAVALWRTWKCQRLNAIPATCRYSR
						

Length

142

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1989

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis. Without E1B 19K function, virus production is compromised because of premature death of host cell. Interacts with Bax protein in cell lysates (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0005521 ; GO:0016020 ; GO:0019050 ; GO:0020002 ; GO:0043066 ;
GO:0044203

Subcellular Location

Host cell membrane . Host nucleus envelope . Host nucleus lamina . Note=Associated with the plasma and nuclear membranes, and with the insoluble nuclear lamina. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available