Results | viHumans

UniProt ID

P0C6Z1

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

BHRF1[Gene ID: 3783706;5176205 ]

Protein Name

Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)

Organism Name

Epstein-Barr Virus (strain AG876) (HHV-4) (Human Herpesvirus 4)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Lymphocryptovirus> Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)> Epstein-Barr Virus (strain AG876) (HHV-4) (Human Herpesvirus 4)

RefSeq

NC_007605.1 ; AJ507799.2

PubMed ID

16490228

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:3783706;vg:5176205

Reactome

Not Available

Sequence

							MAYSTREILLALCIRDSRVHGNGTLHPVLELAARETPLRLSPEDTVVLRYHVLLEEIIERNSETFTETWNRFITHTEHVDLDFNSVFLEIFHRGDPSLGR
ALAWMAWCMHACRTLCCNQSTPYYVVDLSVRGMLEASEGLDGWIHQQGGWSTLIEDNIPGSRRFSWTLFLAGLTLSLLVICSYLFISRGRH
						

Length

191

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

26-05-2009

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0033644 ; GO:0033650 ; GO:0042981

Subcellular Location

♦ Host membrane
♦ Single-pass membrane protein . Host mitochondrion. Note=also observed in the perinuclear region of the cell. .

Domain(s)

Not Available

Motif(s)

MOTIF 89 109 BH1.; MOTIF 142 157 BH2.

Methods of 3D structure generation

X-ray crystallography (2)

Experimetally known structure

2WH6 4OYD

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available