Results | viHumans

UniProt ID

P0C6L8

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

Not Available

Protein Name

Large delta antigen (L-HDAg) (p27)

Organism Name

Hepatitis Delta Virus Genotype I (isolate Japanese M-2) (HDV)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Deltavirus> Hepatitis Delta Virus (HDV)> Hepatitis Delta Virus Genotype I (isolate Japanese M-2) (HDV)

RefSeq

NC_001653.2 ; D01075.1

PubMed ID

2214027 ; 16402678 ; 16903222

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSRSESKGKRAGREQILEQWVDGRKKLEELERDLRKIKKKIKKLEEENPWLGNVKGILGKKDKDGEGAPPAKRARTDQMEVDTGPRKRPLRGGFSDKERQ
DHRRRKALENKKKQLSAGGKNLSKEEEEELKRLTEEDERRERRVAGPSVGGVNPLEGGPRGAPGGGFVPNMQGVPESPFTRTGEGLDVTGNLGFPWDILF
PADPPFSPQSCRPQ
						

Length

214

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

14-04-2009

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0019012 ; GO:0044196 ; GO:0046718 ; GO:0075732

Subcellular Location

Virion. Host nucleus, host nucleolus. Note=isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place (By similarity). .

Domain(s)

DOMAIN 20 195 HDAg.

Motif(s)

MOTIF 66 75 Nuclear localization signal.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available