Results | viHumans

UniProt ID

P0C6K4

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

ORF1

Protein Name

♦Non-structural polyprotein 1A [Cleaved into: VPg
♦ Protein p19
♦ Transmembrane protein 1A
♦ Serine protease p27 (p27) (EC 3.4.21.-)
♦ Protein p20']

Organism Name

Human Astrovirus-1 (HAstV-1)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Astroviridae> Mamastrovirus> Mamastrovirus 1> Human Astrovirus-1 (HAstV-1)

RefSeq

NC_001897.1 ; AJ005695.1

PubMed ID

8021608 ; 8254779 ; 11799197

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MAYGEPYYSSKPDKDFNFGSTMARRQMTPTMVTKLPKFVRNSPQAYDWIVRGLIFPTIGKTYFQRVVVITGGLEDGTYGSFAFDGKEWVGIYPIEHLNLM
SSLKLIHKANALQERLRLSQEEKATLALDVQFLQHENVRLKEMIPKPEPRKIQMKWIIMGAVLTFLSLIPGGYAHSQTNNTIFTDMIAACKYSTETLTEN
LDLRIKLALANITISDKLDAVRQILNFAFVPRAHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSARPGTDLVTLATSHLSGFRMAVLPTIPFHTTMTLWV
MNTLMVCYYFDNLLAITLAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFIRMATVFIGTRFEIRDANGKVVA
TVPTRIKNVAFDFFQKLKQSGVRVGVNEFVVIKPGALCVIDTPEGKGTGFFSGNDIVTAAHVVGNNTFVNVCYEGLMYEAKVRYMPEKDIAFLTCPGDLH
PTARLKLSKNPDYSCVTVMAYVNEDLVVSTAAAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPADFHPVKAPSQVELLKEEI
ERLKAQLNSATENATTVVTQQPSAALEQKSVSDSDVVDLVRTAMEREMKVLRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEKG
LDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQAKPIPAPRTTKQKICPEPEVESQPLDLSQKKEKQSEYEQQVVKST
KPQQLEHEQQVVKPIKPQKSEPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPHRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAY
EAGLEGFLQRVKSKNKAPKNYKGPQKTKGPKTTTH
						

Length

935

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

08-04-2008

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

♦Non-structural polyprotein 1A: contains the viral protease participating in the cleavage of the polyprotein into functional products.
♦ VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

EC

3.4.21.-

Experimentally known GO terms

GO:0004252 ; GO:0008234 ; GO:0016021 ; GO:0033644 ; GO:0070008

Subcellular Location

♦ Host membrane
♦ Multi-pass membrane protein .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

♦ACT_SITE 461 461 Charge relay system
♦ for serine protease activity.
♦ ACT_SITE 489 489 Charge relay system
♦ for serine protease activity.
♦ ACT_SITE 551 551 Charge relay system
♦ for serine protease activity.

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available