Results | viHumans

UniProt ID

P0C1C7

Status

Reviewed

Host

Cynopterus Brachyotis (Lesser Short-nosed Fruit Bat) (Pachysoma Brachyotis) [TaxID: 58060]; Eonycteris Spelaea (Lesser Dawn Bat) (Macroglossus Spelaeus) [TaxID: 58065]; Homo Sapiens (Human) [TaxID: 9606]; Pteropus Hypomelanus (Island Flying Fox) (Variable Flying Fox) [TaxID: 9405]; Pteropus Vampyrus (Large Flying Fox) [TaxID: 132908]; Scotophilus Kuhlii (Lesser Asiatic Yellow Bat) [TaxID: 153297]; Sus Scrofa (Pig) [TaxID: 9823]

Gene Name

P/V/C

Protein Name

Protein W

Organism Name

Nipah Virus

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Paramyxoviridae> Henipavirus> Nipah Virus

RefSeq

NC_002728.1 ; AF212302.2

PubMed ID

10827955 ; 11504554 ; 11514724 ; 11880045 ; 15663869 ; 15140960 ; 15857993

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MDKLELVNDGLNIIDFIQKNQKEIQKTYGRSSIQQPSIKDQTKAWEDFLQCTSGESEQVEGGMSKDDGDVERRNLEDLSSTSPTDGTIGKRVSNTRDWAE
GSDDIQLDPVVTDVVYHDHGGECTGYGFTSSPERGWSDYTSGANNGNVCLVSDAKMLSYAPEIAVSKEDRETDLVHLENKLSTTGLNPTAVPFTLRNLSD
PAKDSPVIAEHYYGLGVKEQNVGPQTSRNVNLDSIKLYTSDDEEADQLEFEDEFAGSSSEVIVGISPEDEEPSSVGGKPNESIGRTIEGQSIRDNLQAKD
NKSTDVPGAGPKDSAVKEEPPQKRLPMLAEEFECSGSEDPIIRELLKENSLINCQQGKDAQPPYHWSIERSISPDKTEIVNGAVQTADRQRPGTPMPKSR
GIPIKKGAQTRNIHLLGRKTCLGRRVVQPGMFEDHPPTKKARVSMRRMSN
						

Length

450

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

16-05-2006

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta). Interacts with host STAT1 protein in the nucleus, blocking it's phosphorylation by IFN-alpha/beta. Also blocks antiviral state induced by Toll-like receptor 3/TLR3 binding to dsRNA.

EC

Not Available

Experimentally known GO terms

GO:0030683 ; GO:0042025

Subcellular Location

Host nucleus .

Domain(s)

Not Available

Motif(s)

MOTIF 439 442 Nuclear localization signal.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available