Results | viHumans

UniProt ID

P09729

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

US9[Gene ID: 3077455 ]

Protein Name

Unique short US9 glycoprotein (Protein HXLF3) (gpUS9)

Organism Name

Human Cytomegalovirus (strain AD169) (HHV-5) (Human Herpesvirus 5)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Cytomegalovirus> Human Cytomegalovirus (HHV-5) (Human Herpesvirus 5)> Human Cytomegalovirus (strain AD169) (HHV-5) (Human Herpesvirus 5)

RefSeq

Not Available

PubMed ID

3031311 ; 2161319 ; 9621030 ; 12533697

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:3077455

Reactome

Not Available

Sequence

							MILWSPSTCSFFWHWCLIAVSVLSSRSKESLRLSWSSDESSASSSSRICPLSNSKSVRLPQYPRGFGDVSGYRVSSSVSECYVQHGVLVAAWLVRGNFSD
TAPRAYGTWGNERSATHFKVGAPQLENDGALRYETELPQVDARLSYVMLTVYPCSACNRSVLHCRPASRLPWLPLRVTPSDLERLFAERRYLTFLYVVLV
QFVKHVALFSFGVQVACCVYLRWIRPWVRGRHRATGRTSREEEAKDD
						

Length

247

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1989

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Influences cell-to-cell spread of virus in polarized cells. Promotes dissemination of virus across cell-cell junctions of polarized epithelial cells, maybe through the association with the cytoskeletal matrix.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0030683 ; GO:0044163 ; GO:0044178 ; GO:0044386

Subcellular Location

♦ Host endoplasmic reticulum membrane
♦ Single-pass type I membrane protein. Host cytoplasm, host cytoskeleton. Host Golgi apparatus membrane
♦ Single-pass type I membrane protein. Note=In polarized cells, colocalizes with F-actin in the cortical cytoskeleton which underlies lateral membranes.

Domain(s)

DOMAIN 72 168 Ig-like H-type.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available