Reviewed
Homo Sapiens (Human) [TaxID: 9606]
TRS1
Protein HHLF1
Human Cytomegalovirus (strain AD169) (HHV-5) (Human Herpesvirus 5)
Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Cytomegalovirus> Human Cytomegalovirus (HHV-5) (Human Herpesvirus 5)> Human Cytomegalovirus (strain AD169) (HHV-5) (Human Herpesvirus 5)
Not Available
Various pathway(s) in which protein is involved
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MAQRNGMSPRPPPLGRGRGAGGPSGVGSSPPSSCVPMGAPSTAGTGASAAATTTPGHGVHRVEPRGPPGAPPSSGNNSNFWHGPERLLLSQIPVERQALT
ELEYQAMGAVWRAAFLANSTGRAMRKWSQRDAGTLLPLGRPYGFYARVTPRSQMNGVGATDLRQLSPRDAWIVLVATVVHEVDPAADPTLGDKAGHPEGL
CAQDGLYLALGAGFRVFVYDLANNTLILAARDADEWFRHGAGEVVRLYRCNRLGVGTPRATLLPQPALRQTLLRAEEATALGRELRRRWAGTTVALQTPG
RRLQPMVLLGAWQELAQYEPFASAPHPASLLTAVRRHLNQRLCCGWLALGAVLPARWLGCAAGPATGTAAGTTSPPAASGTETEAAGGDAPCAIAGAVGS
AVPVPPQPYGAAGGGAICVPNADAHAVVGADAAAAAAPTVMVGSTAMAGPAASGTVPRAMLVVLLDELGAVFGYCPLDGHVYPLAAELSHFLRAGVLGAL
ALGRESAPAAEAARRLLPELDREQWERPRWDALHLHPRAALWAREPHGQLAFLLRPGRGEAEVLTLATKHPAICANVEDYLQDARRRADAQALGLDLATV
VMEAGGQMIHKKTKKPKGKEDESLMKGKHSRYTRPTEPPLTPQASLGRALRRDDEDWKPSRLPGEDSWYDLDETFWVLGSNRKNDVYQRRWKKTVLRCGL
EIDRPMPTVPKGCRPQTFTHEGIQLMGGATQEPLDTGLYAPSHVTSAFVPSVYMPPTVPYPDPAARLCRDMRRVTFSNIATHYHYNAQ
ELEYQAMGAVWRAAFLANSTGRAMRKWSQRDAGTLLPLGRPYGFYARVTPRSQMNGVGATDLRQLSPRDAWIVLVATVVHEVDPAADPTLGDKAGHPEGL
CAQDGLYLALGAGFRVFVYDLANNTLILAARDADEWFRHGAGEVVRLYRCNRLGVGTPRATLLPQPALRQTLLRAEEATALGRELRRRWAGTTVALQTPG
RRLQPMVLLGAWQELAQYEPFASAPHPASLLTAVRRHLNQRLCCGWLALGAVLPARWLGCAAGPATGTAAGTTSPPAASGTETEAAGGDAPCAIAGAVGS
AVPVPPQPYGAAGGGAICVPNADAHAVVGADAAAAAAPTVMVGSTAMAGPAASGTVPRAMLVVLLDELGAVFGYCPLDGHVYPLAAELSHFLRAGVLGAL
ALGRESAPAAEAARRLLPELDREQWERPRWDALHLHPRAALWAREPHGQLAFLLRPGRGEAEVLTLATKHPAICANVEDYLQDARRRADAQALGLDLATV
VMEAGGQMIHKKTKKPKGKEDESLMKGKHSRYTRPTEPPLTPQASLGRALRRDDEDWKPSRLPGEDSWYDLDETFWVLGSNRKNDVYQRRWKKTVLRCGL
EIDRPMPTVPKGCRPQTFTHEGIQLMGGATQEPLDTGLYAPSHVTSAFVPSVYMPPTVPYPDPAARLCRDMRRVTFSNIATHYHYNAQ
788
Not Available
Not Available
01-07-1989
Evidence at protein level
Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
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Alanine (A) | Leucine (L) | ||||
Arginine (R) | Lysine (K) | ||||
Asparagine (N) | Methionine (M) | ||||
Aspartic Acid (D) | Phenylalanine (F) | ||||
Cysteine (C) | Proline (P) | ||||
Glutamine (Q) | Serine (S) | ||||
Glutamic Acid (E) | Threonine (T) | ||||
Glycine (G) | Tryptophan (W) | ||||
Histidine (H) | Tyrosine (Y) | ||||
Isoleucine (I) | Valine (V) |
% Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
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Inhibits the establishment of the antiviral state in the infected cell. Prevents the phosphorylation of the host eukaryotic translation initiation factor eIF-2alpha/EIF2S1 and thus the shutoff of viral and cellular protein synthesis by directly interacting with EIF2AK2/PKR. Also inhibits host autophagy by interacting with host Beclin-1/BECN1.
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Virion . Host cytoplasm . Host nucleus .
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Predicted/Modelled
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Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available